山东医药Issue(37)：19-20,23,3.DOI:10.3969/j.issn.1002-266X.2014.37.007
慢性阻塞性肺疾病急性加重期血清和肽素水平的变化及临床意义
Changes of serum copeptin in patients with acute exacerbation of chronic obstructive pulmonary disease
摘要
Abstract
Objective To explore the levels and clinical significance of copeptin in acute exacerbation of chronic ob -structive pulmonary disease (AECOPD).Methods 90 subjects with AECOPD were divided into on respiroatory faicure group (n=43), respiratory failure group (n=47),and forty healthy as a control group .The levels of serum copeptin of all AECOPD patients before and after treatment and control group were detected .Results Before treatment , the serum copep-tin of the respiratory failure group was(25.31 ±16.33)pmol/L, on respiroatory faicure group was(10.34 ±4.37)pmol/L, all of them were higher than the control group (4.93 ±1.20)pmol/L (all P<0.01),and the respiratory failure group was higher than the no respiratory failure group (P<0.01);after treatment, the serum copeptin of the respiratory failure group was(5.93 ±3.37)pmol/L, on respiroatory faicur group was (5.47 ±1.60)pmol/L,all of them were significantly reduced (P<0.01).Conclusion The levels of serum copeptin is significantly increased in AECOPD patients .The serum copep-tin is expected to be a useful biological index to estimate the AECOPD .关键词
肺疾病,慢性,阻塞性/急性加重期/和肽素Key words
pulmonary disease, chronic, obstructive/acute exacerbations/copeptin分类
医药卫生引用本文复制引用
井军虎,李立宇,李建强..慢性阻塞性肺疾病急性加重期血清和肽素水平的变化及临床意义[J].山东医药,2014,(37):19-20,23,3.基金项目
山西省自然科学基金资助项目（2013011055-3）。 （）
