山东医药Issue(39)：12-14,3.DOI:10.3969/j.issn.1002-266X.2014.39.004
基底细胞样乳腺癌组织中 Apaf-1、Caspase-9的表达变化及意义
Expression and clinical significance of Apaf-1 and Caspase-9 in basal-like breast carcinoma
摘要
Abstract
Objective To observe the changes of Apaf-1, Caspase-9 expression in the basal-like breast cancer ( BLBC) tissues and explore its clinical significance.Methods The expressions of Apaf-1 and Caspase-9 were detected in 43 cases of BLBC( group A) , 57 cases of non-BLBC( group B) and 60 cases of normal breast tissue( group C) by immuno-histochemistry.The relationship between Apaf-1, Caspase-9 expression and clinicopathological features were analyzed.The correlation between Apaf-1 and Caspase-9 expression was analyzed.Results The positive expression rate of Apaf-1 in group A, B, C was 23.3%(10/43), 49.1%(28/57), 75%(45/60) respectively.The difference between each group was significant(all P<0.01).The positive expression rate of Caspase-9 in group A, B, C was 27.9%(12/43), 54.4%(31/57), 85%(51/60) respectively.The difference between each group was all significant(all P<0.01).The expres-sion of Apaf-1 was significantly correlated with the size of tumor, lymph nodes metastasis and the tumor clinical stage( all P<0.05) .The expression of Caspase-9 was significantly correlated with lymph nodes metastasis and the tumor clinical stage (all P<0.05).There correlation between the expression of Apaf-1 and Caspase-9 was significant(r=0.636, P<0.01). Conclusions Apaf-1 and Caspase-9 are lower expressed in BLBC.The abnormal expression of Apaf-1 and Caspase-9 may be closely correlated with the carcinogenesis and development of BLBC.关键词
乳腺肿瘤/基底细胞样乳腺癌/凋亡蛋白酶活化因子1/细胞凋亡蛋白酶9Key words
breast neoplasms/basal-like breast cancer/apoptotic protease activating factor 1/Caspase-9分类
医药卫生引用本文复制引用
张丙信,赵霞,陈雪,周炳娟,赵文明,李金梅,孙吉瑞,张金库..基底细胞样乳腺癌组织中 Apaf-1、Caspase-9的表达变化及意义[J].山东医药,2014,(39):12-14,3.基金项目
河北省卫生厅医学科学研究课题（20130333）。 （）
