山东医药Issue(41)：3-5,3.DOI:10.3969/j.issn.1002-266X.2014.41.002
尿毒症患者肠黏膜免疫屏障功能与容量负荷和营养状况的关系
Relation of intestinal immunologic barrier function with volume and malnutrition status in uremic patients
摘要
Abstract
Objective To evaluate intestinal immunologic barrier function in uremic patients and its relationship with volume and malnutrition status.Methods Sixty uremic patients without hemodialysis, sixty uremic patients undergoing hemodialysis, and thirty healthy people in control group were recruited for this study.Enzyme-linked immunosorben assay ( ELISA) was used to analyze feces secretory immunoglobulin A ( sIgA) to evaluate intestinal immunologic barrier function, fluid status [ evaluated by the inferior vena cava diameter ( IVCD) and the collapsibility index ( CI) ] was measured by B-mode ultrasonic diagnostic equipment.Modified quantitative subjective global assessment ( MQSGA) was used to evaluate nutritional status.The relationship among sIgA, CI, IVCD and MQSGA was assessed.Results The amounts of feces sIgA were significantly lower in hemodialysis group and no-hemodialysis group than those of control group (all P<0.01).The measurements of IVCD were significantly higher in hemodialysis group and no-hemodialysis group than those of control group (all P<0.01).No significant difference of the measurements of IVCD between no-hemodialysis and dialysis group was found.Linear regression was found between sIgA and IVCD, b=-0.264,P<0.01.Negative correlation was found between sIgA and MQSGA, r=-0.591, P<0.01.Conclusions In uremic patients, whether hemodialysis or without hemodialysis, intestinal immunologil barrier is damaged, blood volume is overloaded.The injury degree of intestinal immu-nologic barrier is associated with volume status and nutritional status.关键词
肾功能衰竭/免疫屏障/分泌型免疫球蛋白A/容量负荷Key words
renal failure/immunological barrier/secretory immunoglobulin A/volume load分类
医药卫生引用本文复制引用
王尊松,崔美玉,唐利军,李文斌,魏勇,许冬梅..尿毒症患者肠黏膜免疫屏障功能与容量负荷和营养状况的关系[J].山东医药,2014,(41):3-5,3.基金项目
山东省自然科学基金科研课题（ZR2010HL012）。 （）
