山东医药Issue(42)：8-10,3.DOI:10.3969/j.issn.1002-266X.2014.42.003
乳腺癌患者血浆D-二聚体水平与临床病理特征的关系
Relationship between plasma D-D level and clinical pathologic characterstics in breast cancer
摘要
Abstract
Objective To analyze the correlation between the serum level of D-D and clinicopathologic feature of breast cancer patients, to investigate the clinical value of D-D in therapeutic effect monitoring and prognosis judgement of breast cancer.Methods A total of 189 breast cancer patients were involved in this study, including 129 surgery patients and 60 systemic chemotherapy patients.After a recertification of 6 to 8 months later, the curative effects were collected as 53 cases of complete remission( CR) , 47 cases of partial remission( PR) , 48 cases of stable disease( SD) and 41 cases of progressive disease( PD) .The serum D-D level of all patients were detected by ELISA method at the time of treatment be-fore, 14 days after treatment and 6 to 8 months recertification.The correlation between the serum level of D-D and age, pathological type, TNM-stage, tumor size, lymph node metastasis, surgical treatment, systemic therapy, ER expression, PR expression, HER-2 expression, clinical prognosis of breast cancer were analyzed .Results The serum level of D-D inⅢ, Ⅳstage, tumor size≥5 cm, lymph node metastasis, surgery treatment, systemic chemotherapy were significant higher (P<0.05).The post treatment serum level of D-D in CR, PR patients were significant lower than treatment before (P<0.05).The post treatment serum level of D-D in PD patients were significant higher than treatment before (P<0.05). The serum level of D-D in SD patients showed no significant difference before and post treatment.Conclusions The serum level of D-D in breast cancer was positively correlated with the clinical pathologic characteristics such as TNM-stage, tumor size, lymph node metastasis and prognoses.The serum level of D-D level in breast cancer patients decreased after surgery and systemic treatment.关键词
乳腺癌/D-二聚体/临床病理特征/预后Key words
breast cancer/D-dimer/clinical pathologic characteristics/prognosis judgment分类
医药卫生引用本文复制引用
冯红蕾,崔林,李泽,韩月婷,张鹏..乳腺癌患者血浆D-二聚体水平与临床病理特征的关系[J].山东医药,2014,(42):8-10,3.基金项目
国家高新技术研究发展计划863计划资助项目（2011AA02A111）。 （）
