山东医药Issue(45)：7-9,3.DOI:10.3969/j.issn.1002-266X.2014.45.003
碱性成纤维细胞生长因子对碱烧伤兔眼角膜新生血管的影响
Effect of basic fibroblast growth factor on neovscularization in alkali burned rabbit corneas
摘要
Abstract
Objective To investigate the effect of basic fibroblast growth factor ( bFGF) on the promotion of neovscu-larization in alkali burned rabbit corneas .Methods Establishing the alkali burned rabbit corneas models , and then dev-ided them into two groups .In the experimental group , bFGF was injected into conjunctiva of rabbits every week before lefe eye cornea transplantation , and then observing the formation of new blood vessels of cornea to evaluate the effect of bFGF on the neovscularization .The right eye of rabbit as the control group , only establishing the alkali burned rabbit corneas models and performing the implantations of keratoprothsis .Results The amount of neovascularization in the rabbit's corneas in ex-perimental group was larger than that in contral group statistically ,before or after implantation; The transplantated kerato-prothesis of experimental group grew well , there were no severe complications occurred such as meltage and perforation . Conclusions bFGF has a significant effect on promotion of neovascularization in alkali burned rabbit corneas and decrea -sing the inflammatory reaction .关键词
角膜疾病/角膜移植/成纤维生长因子2/兔Key words
corneal diseases/corneal transplantation/fibroblast growth factor 2/rabbit分类
医药卫生引用本文复制引用
郭立云,张洁莹,孙恒,胡竹林,边慧..碱性成纤维细胞生长因子对碱烧伤兔眼角膜新生血管的影响[J].山东医药,2014,(45):7-9,3.基金项目
云南省应用基础研究计划项目（2013FB109）。 （）
