山东医药Issue(45)：19-22,4.DOI:10.3969/j.issn.1002-266X.2014.45.007
CD86基因启动子－3479 A／C 位点单核苷酸多态性与 ITP 遗传易感性的关系
Relation between CD86 gene-3479 A/C site polymorphism and genetic susceptibility to primary immune thrombocytopenia
吴品 1王智 1陆时运 1赵晓红1
作者信息
- 1. 无锡市第二人民医院，江苏无锡214002
- 折叠
摘要
Abstract
Objective To explore the association between the CD 86 -3479 A/C site ( rs2715267 ) polymorphism and the risk of ITP.Methods Ninety three adult chronic ITP patients and 119 normal controls were enrolled in this study . Genomic DNA was extracted from peripheral blood , and genotyping of -3479 A/C site was performed by using a PCR with sequence specific primers and confirmed by DNA sequencing .Results CD86 gene -3479 A/C site genotype frequencies of AA, AC and CC were 40.9%, 52.6%and 6.5%in ITP patients respectively, and were 49.6%, 37.8%and 12.6%in normal controls respectively (P>0.05).The allele frequencies of A and C were 67.2%and 32.8%in ITP patients re-spectively, and were 68.5%and 31.5% in normal controls respectively(P>0.05).We further subdivided the patients and normal controls according to the sex and clinical responses to glucocorticoids , but still did not find any difference in genotype and allele frequencies between each pair of these subgroups .Conclusion CD86 -3479 A/C polymorphisms may not be associated with the genetic susceptibility to ITP in a Chinese population .关键词
血小板减少/CD86/多态性,单核苷酸Key words
thrombocytopenia/CD86/polymorphism, single nucleotide分类
医药卫生引用本文复制引用
吴品,王智,陆时运,赵晓红..CD86基因启动子－3479 A／C 位点单核苷酸多态性与 ITP 遗传易感性的关系[J].山东医药,2014,(45):19-22,4.
