山东医药Issue(46)：11-13,3.DOI:10.3969/j.issn.1002-266X.2014.46.004
第二代与第三代二膦酸盐对正畸源性牙移动及牙根吸收的影响
Effects of the second and third generation of bisphosphonates on orthodontic root resorption and tooth movement
摘要
Abstract
Objective To compare the effects of pamidronate and ibandronate on orthodontic tooth movement and or -thodontic root resorption .Methods A total of 96 female, 6-week-old SPF Wistar rats were selected and the animal models for orthodontic tooth movement were established .The rats were randomly divided into two groups , which were the pamidr-onate group and the ibandronate group with 48 rats in each group.Pamidronate(50μL) and ibandronate(50μL) were in-jected on the sub-periosteum area adjacent of the first permanent molars every 3 days during the experiment .The rats were executed in batch on the 3, 7 and 14 day during the orthodontic treatment .Eight of them were chosen for histology observa-tion of periodontium and measuring the distances of the tooth movement .The remaining 8 were used for SEM observation of root resorption .Rsesults There is no significant differences between the pamidronate group and the ibandronate group on the movement distance of the first molar .And no significance was discovered between the pamidronate group and the iban-dronate group on the root resorption lacunae .Conclusions Both pamidronate and ibandronate can inhibit orthodontic tooth movement and inhibits orthodontic root resorption .关键词
帕米膦酸钠/伊班膦酸钠/正畸牙移动/牙根吸收Key words
pamidronate/ibandronate/orthodontic tooth movement/root resorption分类
医药卫生引用本文复制引用
张体勇,王旭霞,王胜林,赵姝亚,张君..第二代与第三代二膦酸盐对正畸源性牙移动及牙根吸收的影响[J].山东医药,2014,(46):11-13,3.基金项目
山东省科学技术发展计划项目（2009GG20002042）；济南市科技局科技攻关项目（2010GG01070）。 （）
