山东医药Issue(48)：22-23,2.DOI:10.3969/j.issn.1002-266X.2014.48.007
甲状腺乳头状癌组织中酪氨酸激酶受体第16外显子基因突变情况及意义
Mutation of RET exon 16 in the papillary thyroid cancer and clinical significance
摘要
Abstract
Objective To investigate the mutation of RET exon 16 in papillary thyroid cancer and to discuss its clinical significances .Methods DNA sequencing was performed to detect the mutation in 60 papillary thyroid cancer ( observation group) and twenty normal control group .The mutation were respectively observed in clinical and pathological features of pa -pillary thyroid cancer group .Results In the observation group , 11 cases were found RET exon 16 point mutation that was 918 bases existing C replacement T , no mutation of RET exon 16 was found in control group , P<0.05.The mutation of RET exon 16 was not related to clinical and pathological features in observation group (all P>0.05).Conclusion The mutation of RET exon 16 in papillary thyroid cancer patients increased , which was involved in carcinogenesis .关键词
甲状腺肿瘤/乳头状/酪氨酸激酶受体/基因突变Key words
thyroid neoplasms/papillary/tyrosine kinase receptors/gene mutation分类
医药卫生引用本文复制引用
濮亚斌,李刚强..甲状腺乳头状癌组织中酪氨酸激酶受体第16外显子基因突变情况及意义[J].山东医药,2014,(48):22-23,2.基金项目
上海市长宁区卫生和计划生育委员会科研项目（20134Y16001）。 （）
