摘要
Abstract
Objective To explore the specificity and sensitivity of plasma biomarkers in patients with acute cerebral in-farction for clinical auxiliary diagnosis and a follow-up.Methods A total of 150 cases of acute cerebral infarction patients (ob-served group), 50 cases of healthy controls (control group) were included.Circular enzymatic and ELISA method and immune turbidimetric method were respectively used o determine the plasma homocysteine (Hcy), endothelial nitric oxide synthase (eNOS), soluble thrombus regulatory proteins (sTM), hypersensitive c-reactive protein (hs-CRP) and von willebrand factor (vWF) level.Results The plasma levels of those biomarkers as Hcy, eNOS.sTM, hs-CRP and vWF were significantly higher in observed group than those in healthy control group(P<0.05).Aarea under the ROC curve were respectively 0.938, 0.873, 0.879, 0.922 and 0.786.According to the ROC curve, when the Hcy critical value was 9.11μmol/L, the diagnostic sensitivity was 95.2%, the specificity was 76%.When the eNOS critical value was 437.30 μmol/L, the diagnostic sensitivity was 79%, the specificity was 96%.When the sTM critical value was 7.43 μmol/L, the diagnostic sensitivity was 75.2%, the specificity was 96%.When the hs-CRP threshold was 3.38 mg/L, the diagnostic sensitivity was 81.9%, the specificity was 90%;when the vWF critical value was 194.85 ng/mL, the diagnostic sensitivity was 75.2%, the specificity was 80%.Conclusion The levels of Hcy, eNOS, sTM, hs-CRP and vWF in plasma may be auxiliary biomarkers for the diagnosis of acute cerebral infarction .关键词
脑梗死,急性/同型半胱氨酸/一氧化氮合酶/C反应蛋白质/血栓调节蛋白/血管性假血友病因子Key words
cerebral infarction , acute/Hcy/NOS/CRP/TM/vWF分类
医药卫生
