山东医药Issue(5)：1-3,6,4.DOI:10.3969/j.issn.1002-266X.2015.05.001
血清 PSA、PSAD 检测在前列腺癌骨转移诊断中的价值
Diagnostic value of combining detection of PSA and PSAD in patients with prostate cancer bone metastasis
摘要
Abstract
Objective To investigate the clinical value of PSA , PSAS on prostate cancer with bone metastasis .Meth-ods A total of 238(a group of 112 cases of bone metastasis, a group of 126 cases of non-bone metastasis) patients with his-tologically diagnosed prostate cancer were analyzed .ECT, X-ray, CT and MRI were used to diagnose bone metastasis .Rela-tion among serum PSA and PSAD joint detection and bone metastasis were analyzed .Results According to serum PSA>20 ng/mL diagnostic criteria of bone metastasis , the rate of bone metastasis had significant difference between the two groups ( P<0.05), the sensitivity and specificity were 76.79%and 82.54%, respectively.According to serum PSAD>0.40 ng/(mL · cm3 ) diagnostic oriteria of bone metastasis , the rate of bone metastasis had significant differenc between the two groups ( P<0.05), the sensitivity and specificity were 82.14% and 75.40%, respectively.The sensitivity and specificity of serum PSA+PSAD were 82.14% and 84.13%, respectively .Using ROC curve to determine the diagnosis critical value of PCa bone metastases, the best critical value of serum PSA was 20 ng/mL and the best critical value of serum PSAD both 0.40 ng/( mL· cm3 ) .Conclusions Serum PSA and PSAD are both valuable parameters used in prediction of PCa bone metastasis . Serum PSA and PSAD joint detection can be better to help doctor predicting PCa bone metastasis .关键词
前列腺肿瘤/骨转移/前列腺特异性抗原/前列腺特异性抗原密度Key words
prostate cancer/bone metastasis/prostate specific antigen/prostate specific antigen density分类
医药卫生引用本文复制引用
刘妍,徐勇,刘冉录,张志宏,杨阔..血清 PSA、PSAD 检测在前列腺癌骨转移诊断中的价值[J].山东医药,2015,(5):1-3,6,4.基金项目
天津市应用基础及前沿技术研究计划（12JCYBJC31400）；天津市科委抗癌重大专项攻关计划项目（12ZCDZSY16300）。 （）
