山东医药Issue(5)：4-6,3.DOI:10.3969/j.issn.1002-266X.2015.05.002
G 试验和 GM 试验对儿童恶性血液病侵袭性真菌感染的诊断价值
Diagnostic value of G/GM assay for invasive fungal infections in pediatric patients with hematological malignancies
摘要
Abstract
Objective To evaluate the diagnostic value of serum (1, 3) -β-D-glucan (G assay) and galactomannan (GM assay) for invasive fungal infections in pediatric patients with hematological malignancies .Methods Totally 246 pe-diatric patients with hematological malignancies were selected to our study .According to invasive fungal infections diagnos-tic criteria, they were divided into two groups:infection group (n=27), non-infected group(n=219).The concentration of serum (1, 3) -β-D-glucan and galactomannan was detected by kinetic turbidimetric limulus test and ELISA .The sensi-tivity, specificity, positive predictive value and negative predictive value of GM test and G test and the combination of GM and G tests were calculated in diagnosing IFI .Results The sensitivity, specificity, positive predictive value and negative predictive values of G assay for the diagnosis of pediatric patients with invasive fungal infections were 88.89%, 91.78%, 57.14%and 98.53%, respectively; GM assay results were 66.67%, 71.23%, 22.22% and 94.55%, respectively;The results of G assay with GM assay using parallel analysis were 100%, 65.75%, 26.47%%and 100%, respectively;Using series analysis were 55.56%, 97.26%, 71.43%and 94.67%, respectively.Conclusions The G assay and GM assay were both useful in diagnosis of invasive fungal infections in pediatric patients with hematological malignancies .Using series analysis of G assay and GM assay can improve diagnostic specificity and positive predictive value .关键词
血液病,儿童/侵袭性真菌感染/(1,3)-β-D-葡聚糖/半乳甘露聚糖Key words
hematological malignancies ,pediatric/invasive fungal infections/(1,3)-β-D-glucan/galactomannan分类
医药卫生引用本文复制引用
李泰阶,李萌,郭世辉,梁宏洁,李山,秦雪,刘志明..G 试验和 GM 试验对儿童恶性血液病侵袭性真菌感染的诊断价值[J].山东医药,2015,(5):4-6,3.基金项目
广西壮族自治区卫生厅资助项目（桂卫Z2012092）；广西壮族自治区卫生厅资助项目（桂卫Z2013014）。 （）
