山东医药Issue(11)：14-17,4.DOI:10.3969/j.issn.1002-266X.2015.11.005
99m Tc-MDP 骨扫描在乳腺癌骨转移诊断中的应用
Application of 99m Tc-MDP bone scanning in diagnosis of breast cancer with bone metastasis
摘要
Abstract
Objective To observe application effect of 99m Tc-MDP bone scanning in the diagnosis of breast cancer with bone metastasis.Methods 99mTc-MDP bone scanning of the whole body was performed in 317 cases of patients with breast cancer.A week before 99mTc-MDP bone scanning, fasting venous blood was collected (3.0 mL), and then, the serum carci-noembryonic antigen (CEA), carbohydrate antigen 125 (CA125) and carbohydrate antigen 15-3 (CA15-3) was detected by using the ECL assay .The relationships between serum CEA , CA125, CA15-3 and bone scanning were analyzed by ROC curve, and we calculated CUT-OFF value of CEA, CA125, CA15-3 in diagnosis of breast cancer with bone metastasis .Re-sults 99mTc-MDP bone scanning showed there were 245 cases of patients without bone metastasis (negative), and 72 cases of bone metastasis (positive, 52 cases of gradeⅠ, 20 cases of gradeⅡand above).Compared with the negative bone scanning , the levels of CEA, CA125 and CA15-3 were increased in the patients of bone scanning gradeⅠ,Ⅱand above (all P<0.05);compared with gradeⅠbone scanning , the levels of CEA , CA125 and CA15-3 were increased in patients of bone scanning gradeⅡ(all P<0.05).99mTc-MDP bone scanning showed when the bone scanning reached grade Ⅱand above, the area under the ROC curve of serum CEA , CA125 and CA15-3 was 0.80, 0.98 and 0.88, respectively .The CUT-OFF values of CEA , CA125 and CA15-3 in diagnosis of breast cancer with bone metastasis were 22.35, 38.71 and 41.96 U/mL.Conclusions 99m Tc-MDP bone scanning can be used as a diagnostic tool in the breast cancer with bone metastases screening .When the serum CEA, CA125 and CA15-3 levels are above 22.35, 38.71 and 41.96 U/mL, we should be more vigilant about the oc-currence of multiple bone metastases, which needs for the 99mTc-MDP bone scanning.关键词
99m Tc-MDP骨扫描/乳腺肿瘤/乳腺癌/癌胚抗原/糖链抗原125/糖链抗原15-3Key words
99m Tc-MDP bone scanning/breast neoplasms/breast carcinoma/carcinoembryonic antigen/carbohydrate antigen 125/carbohydrate antigen 15-3分类
医药卫生引用本文复制引用
许守林,冯雪凤..99m Tc-MDP 骨扫描在乳腺癌骨转移诊断中的应用[J].山东医药,2015,(11):14-17,4.基金项目
中央高校基本科研业务费专项资金赞助（20620140661）。 （）
