山东医药Issue(11)：18-20,3.DOI:10.3969/j.issn.1002-266X.2015.11.006
乳腺浸润性导管癌组织中 Mfn2的表达变化及临床意义
Expression changes of Mfn2 in infiltrating ductal carcinoma of breast and the clinical significance
摘要
Abstract
Objective To observe the expression changes of mitofusin 2 ( Mfn2 ) in infiltrating ductal carcinoma of breast and to investigate its clinical significance .Methods The immunohistochemical SP method was used to assess the expression of Mfn2 in 116 cases of infiltrating ductal carcinoma of breast ( observation group ) and 10 cases of normal breast ductal epithelial tissues (control group).The relationships between Mfn2 expression and the clinicopathological parameters of breast infiltrating ductal carcinoma patients were analyzed .Results The positive expression rates of Mfn 2 in the obser-vation and control groups were 44.82%(52/116) and 90.00%(9/10), respectively (all P<0.05).The Mfn2 expres-sion was related with lymph node metastasis, histological grade, TNM staging, estrogen receptor, progesterone receptor and epidermal growth factor receptor-2 of breast infiltrating ductal carcinoma (all P<0.05).Conclusion The Mfn2 expres-sion is decreased in the breast infiltrating ductal carcinoma tissues , which may play an important role in the occurrence and development of infiltrating ductal carcinoma of breast.关键词
乳腺肿瘤/乳腺浸润性导管癌/线粒体融合蛋白2Key words
breast neoplasms/infiltrating ductal carcinoma of breast/mitofusin 2分类
医药卫生引用本文复制引用
谢艳丽,焦俊琴,刘月平,马力..乳腺浸润性导管癌组织中 Mfn2的表达变化及临床意义[J].山东医药,2015,(11):18-20,3.基金项目
河北省医学科学研究重点课题计划项目（ ZL20140021）。 （）
