山东医药Issue(16)：38-40,3.DOI:10.3969/j.issn.1002-266X.2015.16.014
小剂量去氧肾上腺素预防剖宫产患者腰-硬联合麻醉后低血压效果观察
Effects of low-dose of phenylephrine in prevention of hypotension after combined spinal-epidural anesthesia in cesarean patients
摘要
Abstract
Objective To observe the clinical effects of low-dose of phenylephrine in prevention of hypotension after combined spinal-epidural anesthesia ( CSEA) in cesarean patients .Methods Sixty cases of cesarean patients ( ASA I-Ⅱ) were randomly divided into two groups with 30 cases in each group: phenylephrine group ( group A ) and control group (group B).After the CSEA, patients in the two groups all received the liquid coload .For group A, phenylephrine was in-jected within 15 min.The changes of mean arterial pressure ( MAP) and heart rate ( HR) in the two groups were observed and compared before and after anesthesia .At the same time, complications, such as fidget, shiver and vomiting were also recorded.Newborns 1 min and 5min Apgar scores were estimated.Results MAPs in the group A, and HR of the two groups before and after anesthesia were stable (all P>0.05), while MAP was reduced in the group B 10 min after anesthe-sia (P<0.05).The incidence of hypotension was significantly lower , and neonatal 1 min Asgar scores were higher in group A than those of group B (all P<0.05).However, there were no differences in the time from intrathecal injection of medicine to fetal childbirth , operation time, intraoperative infusion and neonatal 5 min Apgar scores between two groups (all P>0.05).Conclusion Low-dose of phenylephrine could effectively prevent hypotension of cesarean patients after CSEA and has a few obvious adverse reactions .关键词
腰-硬联合麻醉/同步负荷/去氧肾上腺素/低血压/剖宫产Key words
combined spinal-epidural anesthesia/coload/phenylephrine/hypotension/cesarean分类
医药卫生引用本文复制引用
路喻清,李欣,杨远东,冯阳阳,张向东..小剂量去氧肾上腺素预防剖宫产患者腰-硬联合麻醉后低血压效果观察[J].山东医药,2015,(16):38-40,3.基金项目
陕西省科学技术攻关项目（ SF2-14）；延安大学研究生科研基金资助项目（12YJ11）。 （）
