山东医药Issue(18)：7-9,3.DOI:10.3969/j.issn.1002-266X.2015.18.003
肝癌组织中 HuR 和 HIF-1α的表达及其相关性
Expression and correlation of HuR and HIF-1αin hepatocellular carcinoma
摘要
Abstract
Objective To investigate the expression and correlation of human antigen R ( HuR) and hypoxia-induc-ible factor (HIF)-1αin hepatocellular carcinoma (HCC) tissues.Methods Forty-eight cases of HCC tissue and adjacent tissue samples were collected from patients undergoing surgical resection .The expression of HuR and HIF-1αprotein in the HCC and adjacent tissues was detected by immunohistochemical staining .The mRNA expression of HIF-1αin the HCC tis-sues was detected by fluorescent quantitative PCR .Results The positive expression rates of HuR and HIF-1αprotein in the HCC tissues were 67%and 58%, respectively .These rates were significantly higher than the positive expression rates of HuR and HIF-1αprotein (19%and 10 %) in the adjacent tissues ( all P<0.01) .The expression of HuR protein was positively correlated with the expression of HIF-1αprotein in the HCC tissues (r=0.723, P<0.01).The mRNA expres-sion of HIF-1αmRNA in the group with high expression of HuR protein was significantly up-regulated as compared with that of the group with low expression of HuR protein (P<0.05).Conclusions The expression of HuR and HIF-1αprotein was up-regulated and positively correlated with each other in the HCC tissues .HuR may enhance the stability of HIF-1αmRNA, and thus increase the expression of HIF-1αprotein.关键词
肝癌/人抗原R/缺氧诱导因子-1α/RNA结合蛋白Key words
liver carcinoma/human antigen R/hypoxia-inducible factor-1α/RNA-binding protein分类
医药卫生引用本文复制引用
刘利平,江建新,鲍世韵,张育森,何婉..肝癌组织中 HuR 和 HIF-1α的表达及其相关性[J].山东医药,2015,(18):7-9,3.基金项目
国家自然科学基金资助项目（81402041、81160311）。 （）
