山东医药Issue(21)：13-16,4.DOI:10.3969/j.issn.1002-266X.2015.21.005
缺血性脑血管病患者脑微出血的危险因素分析
Risk factors of cerebral microbleeds in patients with ischemic cerebrovascular disease
摘要
Abstract
Objective To investigate the risk factors of cerebral microbleeds ( CMB) in patients with ischemic cere-brovascular disease, and to provide clinical basis for the prevention and treatment of stroke.Methods The clinical data of 135 patients with ischemic cerebrovascular disease, including the age, sex, body mass index ( BMI) , height, blood pres-sure, blood glucose, blood lipid, smoking history, drinking history, heart disease and other clinical data, were collected. Meanwhile, the susceptibility-weighted imaging (SWI) was used to detect the CMB, silent lacunar infarction and leukodys-trophy.We compared the clinical characteristics of patients with or without CMB, different parts of CMB and different se-verity of CMB.Logistic regression was used to analyze the risk factors of CMB.Results During 135 patients, 55 cases of patients had CMB, and 80 cases had no CMB.There were 35 cases of deep/infratentorial CMB and 20 cases of lobar CMB in CMB patients.According to the severity, CMB was divided into three levels, level 1 CMB was found in 22 cases, level 2 in 26 case and level 3 in 4 cases.The age, BMI, systolic blood pressure level, the scale of white matter lesion and pro-portion of hypertension, history of stroke and lacunar infarction in deep/infratentorial CMB group were significantly higher than that of non-CMB group ( all P<0.05) .The BMI, proportion of hypertension and lacunar infarction in deep/infraten-torial CMB group were higher than lobar CMB group (all P<0.05).The age and the scale of white matter lesion in lobar CMB group were significantly higher than non-CMB group (all P <0.05).The proportion of hypertension, history of stroke, lacunar infarction and white matter lesion of patients with level 3 and level 2 CMB were significantly higher than those of patients with level 1 CMB (all P<0.05).Multivariate Logistic regression analysis showed that the age, hyperten-sion, history of stroke, asymptomatic lacunar infarction and the white matter lesion were the independent risk factors for CMB (OR=7.536, 0.432, 0.470, 0.413 and 2.158, all P<0.05).Conclusion The patients who have advanced age, hypertension, lacunar infarction, white matter lesion and history of stroke are prone to CMB, and thus, we should pay attention to the possibility of recurrence of stroke.关键词
脑缺血/脑微出血/危险因素Key words
cerebral ischemia/cerebral microbleeds/risk factors分类
医药卫生引用本文复制引用
卢俏丽,李晨,尹延英,王欢,徐梅松,贾志荣..缺血性脑血管病患者脑微出血的危险因素分析[J].山东医药,2015,(21):13-16,4.基金项目
天津市卫生局科技基金项目（2013KZ021）；滨海新区卫生局医药卫生科技项目（2013BWKY025）。 （）
