山东医药Issue(21)：23-25,3.DOI:10.3969/j.issn.1002-266X.2015.21.008
复方红景天对2型糖尿病肾病大鼠尿微量白蛋白、血晚期氧化蛋白产物水平的影响
Effects of compound rhodiola sachalinensis on microalbuminuria and advanced oxidation protein products of rats with type 2 diabetic nephropathy
摘要
Abstract
Objective To observe the changes of microalbuminuria ( mALB) and advanced oxidation protein products ( AOPPs ) of rats with type 2 diabetic nephropathy ( T2DN) by feeding compound rhodiola sachalinensis ( Fufang Hongjin-tian) and to investigate its mechanism of protecting the kidney.Methods Fifty male 8-week-old Wistar rats were random-ly divided into the normal control group (A group, n=5) and model group (n=45).During the 45 rats, 43 rat models with DN were successfully made.Then, they were randomly divided into the model control group (group B, n=10), low dose compound rhodiola sachalinensis group ( group C) , medium-dose compound rhodiola sachalinensis group ( group D, n=11), and high-dose compound rhodiola sachalinensis group (group E, n=11).Rats in the groups C, D and E were treated by 3, 6 and 12 g/( kg· d) compound rhodiola sachalinensis and rats in the group B was treated by intragastric ad-ministration of the same amount of normal saline for 4 weeks.The FBG, FINS, HOMR-IR, TG, TC, AOPPs and 12-hour mALB level in the caudal vein of rats were detected before and after treatment and the body weight ( BW) was also ob-served.Results Before treatment, the BW of group B was significantly lower than that of group A, but FPG, FINS, HOMR-IR, TG, TC, mALB and AOPPs level was higher than that of group A (P<0.05 or P<0.01).After treatment of 4 weeks, the BW of groups C, D and E was higher than that of group B, but FPG, AOPPs and mALB was lower than that of the group B (all P<0.01).No statistical difference was found in FPG, AOPPs and mALB among groups C, D and E (all P>0.05).Conclusion Compound rhodiola sachalinensis (Fufang Hongjingtian) has the protective effect on kidney of T2DN rats by reducing the levels of mALB and AOPPs.关键词
糖尿病肾病/复方红景天/尿微量白蛋白/晚期氧化蛋白产物/大鼠Key words
diabetic nephropathy/compound rhodiola sachalinensis(Fufang Hongjingtian)/urinary microalbumin/advanced oxidation protein products/rats分类
医药卫生引用本文复制引用
李玲华,袁少静,刘杰,王敏,骆岚,隋晨辉,朱济英..复方红景天对2型糖尿病肾病大鼠尿微量白蛋白、血晚期氧化蛋白产物水平的影响[J].山东医药,2015,(21):23-25,3.基金项目
山东省中医药科技发展计划项目（2011-109）。 （）
