山东医药Issue(24)：37-38,39,3.DOI:10.3969/j.issn.1002-266X.2015.24.014
子宫腺肌病患者子宫内膜组织中 ER、PR、SRC-3表达变化及意义
Expression changes and significance of ER, PR and SRC-3 in endometrial tissues of patients with adenomyosis
王琴 1李燕 1唐利 1李宗恒1
作者信息
- 1. 泸州医学院附属医院，四川泸州646000
- 折叠
摘要
Abstract
Objective To observe the expression changes of estrogen receptor (ER), progesterone receptor (PR) and steroid receptor coactivator-3 (SRC-3) in the endometrial tissues of patients with adenomyosis (AM) and to investigate their significance .Methods The expression of ER , PR and SRC-3 was detected by immunohistochemistry and tissue mi-croarray method in the ectopic endometria of 42 AM patients (EE group) and in the normal endometria of 15 patients with hysteromyoma ( NE group) .Results Compared with the NE group , the expression of ER and PR was decreased , and the expression of SRC-3 was increased in the EE group (all P<0.05).The expression of ER, PR and SRC-3 in the prolifera-tive phase of the NE group was higher than that in the secretory phase (all P<0.05).No statistically significant differences were found in ER, PR and SRC-3 of the EE group between the proliferative phase and secretory phase (all P>0.05).In the secretory phase, the ER expression of the EE group was lower than that in the NE group (P<0.05).There was a neg-ative correlation between ER and SRC-3 in the EE group (r=-0.693, P<0.01).Conclusions ER and PR is lowly ex-pressed and SRC-3 is highly expressed in the endometrial tissues of AM patients , and they may be related with the occur-rence and development of AM .关键词
子宫腺肌病/异位内膜/雌激素受体/孕激素受体/类固醇受体辅助活化因子3Key words
adenomyosis/ectopic endometrium/estrogen receptor/progesterone receptor/steroid receptor coactiva-tor-3分类
医药卫生引用本文复制引用
王琴,李燕,唐利,李宗恒..子宫腺肌病患者子宫内膜组织中 ER、PR、SRC-3表达变化及意义[J].山东医药,2015,(24):37-38,39,3.
