陕西中医Issue(7)：922-924,3.DOI:10.3969/j.issn.1000-7369.2015.07.081
脑尔康对AD模型小鼠学习记忆及脑内AchE活性影响的拆方研究
Experimental study on decomposing prescription of Naoerkang to effect the learning and memory and AchE activity in the brains of AD mice
摘要
Abstract
Objective:Decompose the Naoerkang to screen one decomposed prescription which has better effect but has fewer ingredients on Alzheimer’s Disease mice .Methods:70 mice were randomly divided into 7 groups ,10 for each group ,injected AlCl3 solution into stomach to made the AD model .Mice of the control and the model groups had been forced to drink saline 0 .5mL per day ;and mice of the other groups had been forced to drink the response medicine , 14 .3g/kg per day ,for 30 days .observed the learning and memory ability and AchE activity in right cortex and hippocam‐pus in each mouse .Result :Compared with the model group ,the whole group and decomposed 1 improved the learning and memory functions obviously(P<0 .05 or P<0 .01) ,decreased the AchE activity obviously(P<0 .01) ,increased the protein level evidently(P<0 .05 or P<0 .01) in hippocampus and cortex .All of its decomposed prescriptions compared with the whole group ,there were no significant differences existed in decomposed prescription 1 and the whole group , there were significant differences existed in decomposed prescription 2 ,3 ,4 and the whole group(P<0 .05 or P<0 .01) . Compared with the decomposed prescription 1 ,there were significant differences (P<0 .05 or P<0 .01) existed in decom‐posed prescription 2 ,3 and 4 except for increasing the protein level in hippocampus of decomposed prescription 2 .Conclu‐sions :decomposed prescription 1 and Naoerkang groups both have better effect of improving the learning and memory functions and inhabiting the AchE activity than any other decomposed prescription ,they have the same effect ,but the for‐mer has fewer ingredients .关键词
脑尔康/阿尔茨海默病/学习记忆/乙酰胆碱酯酶活性/拆方研究Key words
NaoErkang/Alzheimer’s disease/Learning and memory/AchE activity/Decomposing prescriptions分类
医药卫生引用本文复制引用
马新欣,李玺,田苑,王娟..脑尔康对AD模型小鼠学习记忆及脑内AchE活性影响的拆方研究[J].陕西中医,2015,(7):922-924,3.基金项目
陕西省科技发展攻关项目［2007K15-05（3）］ （）
