世界中医药Issue(5)：541-544,548,5.DOI:10.3969/j.issn.1673-7202.2014.05.001
基于偏最小二乘法的中医临床肝炎肝硬化主、次证候分类特征研究
Studies on Characteristics of TCM Syndromes of Patients with Post-hepatitic Cirrhosis based on Method of Partial Least-Squares
摘要
Abstract
Objective:To study the clinical characteristic of the main syndromes and concurrent syndromes of the patients with post -hep-atitic cirrhosis using the method of partial least-squares.Methods: Criteria for case-included, case-excluded and biological information (symptoms, signs, tongue, pulse and biological parameters ) harvesting and inputting was established .Stepwise regression was used to analyze the clinical information , including clinical symptoms , biological parameters and TCM syndromes , which were obtained from 278 patients with posthepatitic cirrhosis by means of clinical epidemiological research .Mathematical models were obtained by Leave-One-Out in partial least squares program .Results:For the 278 patients with posthepatitic cirrhosis , damp-heat brewing internally (79 cases) and stasis heat in the interior (108 cases) were the most common syndromes .Among the 261 cases whose patterns could be identified , 215 cases (82.38%) were vacuity with repletion complication .Among the 45 patients with liver-kidney yin vacuity syndrome , 29 patients had one concurrent syndrome including 18 cases of damp-heat brewing internally and 11 cases of stasis heat in the interior , and the left cases had two concurrent syndromes including damp-heat brewing internally and stasis heat in the interior .Among the 79 patients with damp-heat brewing internally , 53 patients had one concurrent syndromes including 47 cases of liver depression and spleen vacuity , and 6 cases of stasis heat in the interior , and the left 9 cases had two concurrent syndromes namely liver depression and spleen vacuity and stasis heat in the interior .Among the 124 cases with damp-heat brewing internally or liver depression and spleen vacuity , 76 cases had both of these two syndromes;all 29cases with liver-kidney yin vacuity had the concurrent syndrome of stasis heat in the interior ;and a-mong the 108 cases with stasis heat in the interior , 78 patients had one concurrent syndrome .It was hard to obtain the conclusion of spleen-kidney yang vacuity syndrome due to the limited quantity of case .Conclusion:Among the 4 main syndromes of posthepatitic cir-rhosis , the most common combinations of concurrent syndromes are liver depression and spleen vacuity /damp-heat brewing internally and stasis heat in the interior/liver-kidney yin vacuity .The distribution of syndromes represents that “vacuity with repletion complication” is the clinic character of posthepatitic cirrhosis .关键词
肝炎后肝硬化/中医证候/兼夹证/偏最小二乘法Key words
Posthepatitic cirrhosis/Traditional Chinese medicine syndrome/Concurrent syndromes/Partial least squares分类
医药卫生引用本文复制引用
张华,王磊,苏越,张琴,刘平..基于偏最小二乘法的中医临床肝炎肝硬化主、次证候分类特征研究[J].世界中医药,2014,(5):541-544,548,5.基金项目
国家重点基础研究发展（973计划）计划资助项目（编号2006CB504801）；国家中医药管理局中医肝胆病重点学科（编号sh2010）；上海市中医临床重点实验室；上海市教育委员会E-研究院建设计划资助项目 （）
