世界中医药Issue(5)：557-560,567,5.DOI:10.3969/j.issn.1673-7202.2014.05.005
胃溃疡活动期“毒热”创新病因的系统研究
Systematic Study on“Toxin-heat” as an Innovative Etiology of Gastric Ulcer in Active State
摘要
Abstract
Objective:To enrich and develop the theory and practice of TCM etiology , taking “toxin-heat” etiological study of gastric ulcer in active state ( GUIAS) as a breakthrough , to establish the research methods of TCM etiology and elucidated the therapeutic mech -anism of GUIAS TCM therapy .Methods:By theoretical analyses , experiments , clinical epidemiological investigations , clinical trials of Chinese medicine , we systematically analyzed the role of “toxin-heat” etiological factor in gastric ulcer in active state .Results:Case-control studies revealed that 83.3%out of 581 patients with GUIAS presented a “toxin-heat” syndrome which was only diagnosed in 13. 3%of 266 patients with superficial gastritis .Multiple logistic regression analysis further confirmed that “toxin-heat” could lead to heli-cobacter pylori infection , bile reflux, increase of inflammatory factors and abnormal secretion of gastrointestinal hormone , etc.In a 300-patient-involved clinical trial , syndrome analyses and gastroscopy showed that the effective rate of the treatments was as high as 86.62%and 80.29%, respectively.Besides, this project modified the animal model and its evaluation method , and verified the efficacy of TCM extract and elucidated the underlying biological mechanism .Conclusion: “Toxin-heat” is a common and frequent cause of GUIAS . Treating GUIAS as carbuncle is a new and effective way for GUIAS therapy , which is capable of clearing heat , detoxifying , and elimina-ting carbuncle while growing muscle .关键词
毒热/以痈论治/胃溃疡(活动期)/溃得康颗粒Key words
Toxin-heat/Treatment of carbuncle/Gastric ulcer ( active stage )/Kuidekang granule分类
医药卫生引用本文复制引用
郑洪新,王垂杰,王文萍,才丽平,傅海燕,曲怡,周学文..胃溃疡活动期“毒热”创新病因的系统研究[J].世界中医药,2014,(5):557-560,567,5.基金项目
国家“973”计划课题基于“以痈论治”胃癌前状态性疾病（胃溃疡活动期）“毒热”病因创新研究 （）
