世界中医药Issue(5)：623-626,4.DOI:10.3969/j.issn.1673-7202.2014.05.026
糖脂平对胰岛素抵抗大鼠糖脂代谢的影响
Effects of Tangzhiping on Glucose and Lipid Metabolism in Insulin-Resistance Rat Model
摘要
Abstract
Objective:To investigate the effects of Tangzhiping on glucose and lipid metabolism in rats with insulin resistance .Meth-ods:Sixty male SD rats which were 8 weeks old and weighted among 180 to 200 g were randomly divided into blank control group ( n=15) and module group (n=45) after being fed for a week for adaptation .Rats in the blank control group were fed with common food , while module group fed the rats with high fat food for 8 weeks.Eight weeks later, the model rats were successfully made , and they were randomly divided into:the model group (n=15), Tangzhiping group (n=15), rosiglitazone group (n=15).Tangzhiping group gave the rats Tangzhiping formula particles according to the statement 20 g/kg/d to fill in the stomach;rosiglitazone group applied up to 0.8 mg/kg/d rosiglitazone gavage;model group and blank control group used the same amount of saline solution for 8weeks.Twelve hours after the last administration , levels of insulin sensitivity was evaluated by the “euglycemic hyperinsulin clamp technique”, and levels of body weight, fast plasma glucose, serum insulin, blood lipids were also observed .Results:Tangzhiping could raise insulin sensitivity , improve IR, suppress weight gain which was better than rosiglitazone;it could lower blood sugar, reduce serum insulin, TG and LDL-c, which was close to the efficacy of rosiglitazone .Conclusion: IR model is successfully established .Tangzhiping and rosiglitazone can lose weight , reduce blood sugar and insulin levels , adjust blood lipid levels and increase insulin sensitivity .关键词
胰岛素抵抗/糖脂平/糖脂代谢/胰岛素敏感性Key words
Insulin Resistance/Tangzhiping/Glucose and lipid metabolism/Insulin sensitivity分类
医药卫生引用本文复制引用
赵轩,高彦彬,周盛楠,李娇阳,朱智耀,张娜..糖脂平对胰岛素抵抗大鼠糖脂代谢的影响[J].世界中医药,2014,(5):623-626,4.基金项目
北京市自然科学基金项目 （）
