世界中医药Issue(9)：1206-1209,4.DOI:10.3969/j.issn.1673-7202.2014.09.029
苹果多酚对卡介苗联合脂多糖所致小鼠免疫性肝损伤的保护作用
Hepatoprotective Role of Apple Polyphenols against Immunological Liver Injury in Mice
摘要
Abstract
Objective:To observe hepatoprotective role of apple polyphenols (AP,Appjfnol )on immunological liver injury in mice. Methods:An immunological liver injury model in mice was established by intravenous injection of Bacillus Calmette-Guerin (BCG)and lipopolysaccharide (LPS).The liver index and spleen index,the activities of serum aspartate aminotransferase (AST)and alanine ami-notransferase (ALT),the levels of serum total protein (TP),albumin (Alb)and albumin/globulin (A /G)were detected.Histopatho-logic change was also investigated by HE staining.Results:AP inhibited the increases of liver index and spleen index,prevented the in-crease of serum AST activity and the decrease of serum TP and Alb levels.Histopathological abnormalities were also improved after AP administration.Conclusion:AP played a significant hepatoprotective role against BCG and LPS induced immunological liver injury in mice.关键词
苹果多酚/卡介苗/脂多糖/免疫性肝损伤Key words
Apple polyphenols/Bacillus Calmette-Guerin/Lipopolysaccharide/Immunological liver injury分类
医药卫生引用本文复制引用
王芳,薛杨,杨静玉,王欢,吴春福..苹果多酚对卡介苗联合脂多糖所致小鼠免疫性肝损伤的保护作用[J].世界中医药,2014,(9):1206-1209,4.基金项目
沈阳市科学技术项目计划资助 （）
