世界中医药Issue(12)：1575-1580,6.DOI:10.3969/j.issn.1673-7202.2014.12.005
健康成人合谷穴、后溪穴的针刺 fMRI 比较研究
An fMRI Study on Needling in Hegu(LI4)and Houxi(SI3)of Adult Healthy Volunteers
摘要
Abstract
Objective:To explore the neurophysiological mechanisms of acupuncture on Hegu(LI4)and Houxi(SI3)curing diseases and the functional specificity of them based on the technique of fMRI.Methods:Forty healthy right-handed volunteers,divided into Hegu (LI4)point group and Houxi(SI3)point group,20 cases in each group.The experiment took the modified block design.All healthy vol-unteers were stimulated at left Hegu(LI4)or Houxi(SI3),acquiring the fMRI data with the same scanning sequences.All fMRI data were analyzed by AFNI program and the results were corrected with Monte Carlo method(P =0.002,α≤0.05).Results:1)Many brain areas were actived with increased signal by stimulating at the left Hegu(LI4)which included:bilateral cerebellum,right thalamus and subthalamic nucleus,bilateral lentiform nucleus and putamen,right caudate,right cingulate gyrus,bilateral precentral gyrus,right posterior central gyrus,bilateral superior parietal lobule,right inferior parietal lobule,left inferior frontal gyrus,right middle frontal gyrus,right mid-dle temporal gyrus,bilateral superior temporal gyrus,right supramarginal gyrus,left middle occipital gyrus,left insula.2)As well as many brain areas were actived with increased signal by stimulating at the left Houxi(SI3)which included:bilateral cerebellum,left thala-mus and ventral posterior medial,right caudate,right precentral gyrus,right middle frontal gyrus,left cingulate gyrus,bilateral insula.3) It showed significant defferences between the Intergroup analysis results of stimulating at Hegu(LI4)vs Houxi(SI3):the increased signal in left cingulated,precentral gyrus and decreased signal in right middle frontal gyrus,inferior frontal gyrus of Hegu(LI4)than Houxi (SI3).Conclusion:Present research directly illustrated the link of Hegu(LI4)with the face and mouth,as well as Houxi(SI3)with the neck and torso at the levels of central nervous system.And it also offered the objective neurophysiological evidence to the traditional Chi-nese medical theory-“fall and hand controlled by Hegu”and “Houxi associating with the governor vessel”.In addition,it explained the mechanism of Hegu treatment to hyperhidrosis,Houxi(SI3)treatment to neck lumbar diseases,and the analgesic function of both acu-points in some degree.Nevertheless,it provided the objective basis of functional specificity of the acupoints which were closed in loca- <br> tion.关键词
针刺/合谷穴/后溪穴/功能特异性/功能磁共振成像Key words
Acupuncture/Hegu acupoint(LI4)/Houxi acupoint(SI3)/Functional specificity/fMRI分类
医药卫生引用本文复制引用
杨骏,黄建军,卢琦,李传富,徐春生,张庆萍,陈东晓,汪林英,朱一芳,张威,武媛媛..健康成人合谷穴、后溪穴的针刺 fMRI 比较研究[J].世界中医药,2014,(12):1575-1580,6.基金项目
国家重点基础研究发展计划（“973”计划）项目病理状况下面口部与合谷穴区联系的脑功能和突触可塑性研究（编号2010CB530505）；国家自然科学基金项目基于多模态功能性磁共振成像针刺穴位脑机制偏侧性研究（编号81202768）；安徽省教委重大科研项目设备场强等关键因素对针刺脑功能成像的影响（编号KJ2011ZD05）；安徽省自然科学基金项目针刺脑功能成像个体差异及其与中医体质类型的关系研究 （）
