世界中医药Issue(12)：1595-1598,4.DOI:10.3969/j.issn.1673-7202.2014.12.009
疏肝健脾法治疗腹泻型肠易激综合征的临床研究
Clinical Study on Liver-Dispersing and Spleen-Strengthening Treatment on Diarrhea Predominant Irritable Bowel Syndrome
摘要
Abstract
Objective:To observe the clinical curative effect of treating the diarrhea predominant irritable bowel syndrome with treatment of liver-dispersing and spleen-strengthening and to explore the objective parameter of IBS-D.Methods:Sixty patients were randomly di-vided into two groups for a double-blinded control study.The treatment group received the decoction of Tong Xie Yao Fang and the con-trol group received Pinaverium Bromide.The treatment course was 4 weeks.The score of symptom was recorded before treatment,and 2 and 4 weeks after treatment.The changes of plasma contents gastrointestinal hormone,5-hydroxytyptam-ine(5-HT),calcitoningene-re-latedpeptide(CGRP),vasoactiveintestinalpeptide(VIP),cholecystokinin(CCK)were evaluated.Results:1)As for syndromes of TCM:The effective rate of the treatment group was 88.9%,while that of the control group was 65.2%,and the difference between the two groups was statistically significant(P <0.05).2)The decoction of Liver-Dispersing with Tong Xie Yao Fang effectively improved the main single-symptoms such as abdominal pain,diarrhea,distention,depression,and irritableness.Especially in terms of the improve-ment of diarrhea,depression,and irritableness,the treatment group showed better outcomes compared to significant Pinaverium Bromide (P <0.05).3)Plasma contents of 5-HT,VIP,CGRP,CCK in each group were all decreased in different degree after treatment.The were more obvious improvement in the treatment group,especially in CGRP (P <0.05).Conclusion:The therapy of liver-dispersing with spleen-strengthening treating IBS-D has a good clinical curative effect and can improve the level of patientsgastrointestinal hor-mone.关键词
肠易激综合征/腹泻型/疏肝健脾法/胃肠激素Key words
Irritable bowels syndrome/Diarrhea predominant/Liver-Dispersing and Spleen-Strengthening/Gastrointestinal hormone分类
医药卫生引用本文复制引用
彭美哲,王思玉,李享,陈思,李帷,张琳,朱培一,汪红兵..疏肝健脾法治疗腹泻型肠易激综合征的临床研究[J].世界中医药,2014,(12):1595-1598,4.基金项目
北京市科学技术委员会首都临床特色应用研究 （）
