世界中医药Issue(12)：1633-1635,1639,4.DOI:10.3969/j.issn.1673-7202.2014.12.019
醒脾解郁方对抑郁模型大鼠抑郁行为和血清5-羟色胺、皮质酮的影响
The Effect of Xingpijieyu Decoction on Depressive Behavior and Serum 5-HT as well as Corticosterone of Depression Rats from Chronic Stress
摘要
Abstract
Objective:To preliminarily explore the effect of Xingpijieyu decoction on depressive behavior and serum 5-HT and corticos-terone on depression model rats.Methods:SD rats were randomly divided into 4 groups:normal group,model control group,sertraline control group,and traditional Chinese medicine (stone calamus,American ginseng,radix curcumae,cultivated land)group.21 days chro-nic unpredictable mild stress was adopted to establish the rat model of depression,using sucrose preference and open-field test to evaluate depression of rats,and compare the change of 5-HT and corticosterone form every groups of rats by ELISA.Results:After 21 days of chro-nic stress depression rats model made,compared with normal group,weight,preference for sugar water rate and open-field total distance of the model group were significantly decreased (P <0.01),and serum corticosterone increased significantly (P <0.01),serum 5-HT sig-nificantly decreased (P <0.01);Compared with model group,sertraline group and Chinese medicine group both could improve depres-sive behavior (P <0.05),and reverse serum 5-HT and corticosterone significantly (P <0.05).Conclusion:Xingpijieyu Decoction can improve chronic unpredictable stress depression rats model depression function,which is the same as sertraline controls.Xingpijieyu de-coction also could reverse erum 5-HT and corticosterone from depression rats,which might be related to its improvement of depression.关键词
慢性不可预见性应激/抑郁症/醒脾解郁法/5-HT/皮质酮Key words
Chronic unpredictable stress/Depression/5-HT/Corticosterone/Xingpijieyu decoction分类
医药卫生引用本文复制引用
王椿野,郭蓉娟..醒脾解郁方对抑郁模型大鼠抑郁行为和血清5-羟色胺、皮质酮的影响[J].世界中医药,2014,(12):1633-1635,1639,4.基金项目
国家自然科学基金面上项目 （）
