世界中医药Issue(12)：1640-1643,4.DOI:10.3969/j.issn.1673-7202.2014.12.021
胰高血糖素样肽-1在中医振腹疗法治疗2型糖尿病中的机制探讨
Study on Mechanism of TCM Abdominal Vibration Therapy Curing Type 2 Diabetes Mellitus via GLP-1 Pathway
摘要
Abstract
Objective:The study was to explore the effect of TCMabdominal vibration treatment on glucagon -like peptide -1 (GLP-1) and rats glucose metabolism.Methods:To induced animal models of type 2 diabetes with Long-term high glucose and lipid diet and a small dose of streptozotocin (STZ,30mg·kg-1 ,ip).Rats were randomly divided into control group,model group,western medicine group,abdominal vibration group,western medicine plus abdominal vibration group.Results:After treatment,the weight of abdominal vibration group was significantly reduced compared to T2DM model group.Weight reduction was more significant in western medicine plus abdominal vibration group than in western medicine group (P <0.05).GLP-1 increased significantly in abdominal vibration group, western medicine group,western plus abdominal vibration group (P <0.05).The pathological slice of Islet beta cell showed that west-ern medicine plus abdominal vibration group was least damaged,followed by abdominal vibration group,western medicine group and model group.Conclusion:Abdominal vibration therapy can reduce serum glucose,relieve diabetes symptoms and cell damage via GLP-1 pathway.关键词
振腹疗法/2 型糖尿病/胰高血糖素样肽-1/空腹血糖/胰岛 β细胞及小肠形态Key words
Abdominal vibration therapy/Type 2 diabetes mellitus (T2DM)/Glucagon -like peptide -1 (GLP-1)/Fasting plasma glu-cose/Islet beta celland intestinal morphology分类
医药卫生引用本文复制引用
范德宇,姜默琳,冒慧敏,季然,李铭,林彩霞,陈幼楠..胰高血糖素样肽-1在中医振腹疗法治疗2型糖尿病中的机制探讨[J].世界中医药,2014,(12):1640-1643,4.基金项目
北京市共建项目课题 （）
