世界中医药Issue(1)：73-74,79,3.DOI:10.3969/j.issn.1673-7202.2015.01.019
通痹外敷散对大鼠弗氏完全佐剂性膝关节炎的实验研究
Laboratory Research of Tongbi Application Powder for Treating Freund’s Adjuvant Knee Arthritis in Rats
邹佩霞 1李莉 2刘兴林 2陈德森2
作者信息
- 1. 湖北医药学院附属太和医院儿科门诊，十堰，442000
- 2. 湖北医药学院机能实验室 十堰，442000
- 折叠
摘要
Abstract
Objective:To observe effect of Tongbi Application Powder on Freund’s adjuvant knee arthritis in rats and its mecha-nism.Methods:Rats were randomly divided into model group and treatment group, sc.injected Freund’s adjuvant 0.1ml into right knee, then measured interleukin-1 beta (IL-1 β), hyaluronic acid (HA) before surgery,1wk, 2wk, 3wk after surgery;measured volume below the right toe.Results:After wk2 , treatment group had lower IL-1 beta and higher HA levels, significantly different compared with that before treatment and model group ( P<0.05) .The treatment group’s extent of foot swelling and dura-tion was significantly better than that of model group, ( P<0.05) .Conclusion:Tongbi Application Powder is effective for treating Freund’s adjuvant arthritis in rats, the effect may be induced by inhibiting IL-1 βsynthesis and increasing HA level.关键词
通痹外敷散/膝关节炎/细胞介素-1β亚型/透明质酸Key words
Tongbi external powder/Knee arthritis/Interleukin-1 subtype/Hyaluronic acid分类
医药卫生引用本文复制引用
邹佩霞,李莉,刘兴林,陈德森..通痹外敷散对大鼠弗氏完全佐剂性膝关节炎的实验研究[J].世界中医药,2015,(1):73-74,79,3.
