世界中医药Issue(2)：236-242,7.DOI:10.3969/j.issn.1673-7202.2015.02.022
肾康灵调控系膜细胞炎性反应因子的机制研究
Study on Mechanism of Shenkangling Regulating Inflammatory Factor of Mesangial Cells
摘要
Abstract
Objective:To clarify the mechanism of Shenkangling on mesangial cells and to observe oxidized low density lipoprotein (ox-LDL)induced Mesangial Cells(MCs)secretion of inflammatory cytokine.Methods:MCs were treated with Shenkangling,and the levels of the inflammatory cytokines,such as CXCL1 6,CD36,IFN-γ,IL6,TNF-αby ELISA,Real Time-PCR and Western blot were detected.Results:The levels of CXCL1 6,CD36,IFN-γ,IL6,TNF-αwere significantly increased after CXCR6 joined and ox-LDL induced mesangial cell proliferation,then all levels were significantly reduced by Shenkangling in a concentration dependent manner.Conclusion:ox-LDL may promote the release of inflammatory mediators such as in mesangial cells,and CXCR6 may medi-ate this path.Shenkangling has effects for ameliorating ox-LDL-induced MC proliferation and inflammatory reactions.关键词
肾康灵/系膜细胞/氧化低密度脂蛋白/CXCL16/CD36Key words
Shenkangling/Mesangial cells/Oxidized low-density lipoprotein/CXCL1 6/CD36分类
医药卫生引用本文复制引用
艾斯,郑健,林青,邱彩霞,林雄,宋艳芳..肾康灵调控系膜细胞炎性反应因子的机制研究[J].世界中医药,2015,(2):236-242,7.基金项目
本课题由福建省自然科学基金面上项目（编号2011 J011 99）；国家自然科学基金青年基金项目（编号81202835）；福建省卫生厅青年基金项目 （）
