世界中医药Issue(3)：423-426,4.DOI:10.3969/j.issn.1673-7202.2015.03.031
响应面法优化一叶种子壳中一叶碱的提取工艺
Extraction Optimization of Securinine from Suffrutescent Securinega Seeds by Response Surface Method
摘要
Abstract
Objective:To optimize the extraction of securinine from the seeds of Suffrutescent securinega by response surface meth-od.Methods:The seeds were soaked and extracted by acid water,and the extraction was subjected to ion exchange column. Crude securinine was further condensed by Saxhlet extraction method.Single factor experiment and Box-Behnken Design method were used to determine the arrangemengt of parameters.Quadratic regression analysis were used to optimize the data by Design-Ex-pert software.Results:The optimal parameter of production technology is finally determined as three times of extraction,with 85% ethanol concentration and 4.7‰ acid concentration.Conclusion:The optimized extraction technology is practicable.关键词
一叶碱/提取工艺/优化设计/响应面法/最优参数Key words
Securinine/Extraction Technology/Optimized design/Box-Behnken design/Optimal parameter分类
医药卫生引用本文复制引用
昌妍希,张屏,包保全..响应面法优化一叶种子壳中一叶碱的提取工艺[J].世界中医药,2015,(3):423-426,4.基金项目
教育部留学回国人员科研启动项目“基于四味土木香散药效物质基础的新剂型开发” （）
