世界中医药Issue(6)：862-864,868,4.DOI:10.3969/j.issn.1673-7202.2015.06.015
“消银解毒饮”对银屑病血热证外周血淋巴细胞调控作用研究
Study on Regulation Role of Xiaoyinjiedu Drink on Peripheral Blood T-lymphocytes in Blood-heat Syndrome of Psoriasis Patients
摘要
Abstract
Objective: To explore the regulation role of Xiaoyinjiedu drink on peripheral blood T-lymphocytes in blood-heat syn-drome of Ps(Psoriasis)patients by observing peripheral blood T lymphocytes and the expression of co-stimulatory factor changes of normal and Psoriasis patients,who received Xiaoyinjiedu Drink.Methods:Treatment group was given 8 weeks of medication,using flow cytometry,while comparison was made to the control group in terms of Peripheral Blood T-lymphocytes and Co-stimulatory fac-tor CD28,CD80,CD86.Results:The treatment group’s lesion scores decreased after treatment;CD3 +,CD4 +and CD4 +/CD8 + is reduced when compared with normal group before and after treatment;CD28 was higher than the normal group before treatment, but lower than normal group after treatment;CD86 was significantly higher than the normal group before and after treatment;There was no significant difference between the normal group and treatment before,but after treatment there was a downward trend in CD80.There was no significant difference in the peripheral T-lymphocytes CD3 +,CD4 +,CD8 +,CD4 +/CD8 + and Co-stimula-tory factor CD28,CD80,CD86 before and after treatment in the treatment group.Conclusion:Xiaoyinjiedu Drink has positive clin-ical effect.Psoriasis patients’peripheral blood T-lymphocytes and Co-stimulatory factor have abnormal expression.It is uncertain whether the improvement of clinical symptoms of patients and the expression of T-lymphocytes and Co-stimulatory factor are parallel related.关键词
消银解毒饮/银屑病血热证/T 淋巴细胞/共刺激因子Key words
Xiaoyinjiedu Drink/Blood-heat Syndrome of Ps/T-lymphocytes/Co-stimulatory factor分类
医药卫生引用本文复制引用
张凯辉,段行武..“消银解毒饮”对银屑病血热证外周血淋巴细胞调控作用研究[J].世界中医药,2015,(6):862-864,868,4.基金项目
国家自然科学基金项目（编号81273755）---新型 T 辅助细胞亚群 Th17、Th22及效应因子 IL-22与银屑病辨证论治关系的研究 （）
