黄芪多糖对四氯化碳诱导的大鼠肝纤维化的保护作用OACHSSCDCSTPCD
Protective Effect of Astragalus Polysaccharide on Liver Fibrosis Induced by Carbon Tetrachloride in Rats
目的：观察黄芪多糖（APS）对四氯化碳（CCl4）致大鼠肝纤维化的治疗作用。方法：采用 CCl4诱导大鼠肝纤维化模型，造模成功后，取大鼠血清和肝组织进行检测。测定血清肝纤维化四项、肝脏组织中羟脯氨酸（HYP）含量；HE 染色比较炎症及肝纤维化程度；免疫组织化学法分析肝组织中 I 型胶原（Col －I）、平滑肌肌动蛋白α（α－SMA）表达量。结果：与模型组相比，APS 中、高剂量组的肝纤四项水平、炎症及肝纤维化程度明显降低（P ＜0．05）；APS…查看全部>>
Objective:To study the protective effect of the Astragalus polysaccharides (APS)on liver fibrosis in rats caused by carbon tetrachloride (CCl4 ).Methods:CCl4 was used to induce rat liver fibrosis model.After making the model successfully,rat serum and liver tissue were collected to test.The serum liver fiber four and hydroxyproline (HYP)content in the liver tissue was tested;HE staining of liver tissue was used to compare inflammation and degree of liver fib…查看全部>>
张晨;黄进;詹菲;张进
广州中医药大学基础医学院，广州，510006广州中医药大学门诊部，广州，510405广州中医药大学基础医学院，广州，510006广州中医药大学基础医学院，广州，510006
医药卫生
肝纤维化黄芪多糖四氯化碳
Liver fibrosisAstragalus polysaccharidesCarbon tetrachloride
《世界中医药》 2015 (6)
887-890,4
广州中医药大学高等学校博士学科点专项科研基金项目（编号20114425120015）
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