世界中医药Issue(7)：1022-1025,4.DOI:10.3969/j.issn.1673-7202.2015.07.015
龙胆泻肝汤加减对带状疱疹的临床疗效观察及对免疫功能的影响
Clinical Curative Effect Observation of Modified Longdan Xiegan Decoction on the Treatment of Herpes Zoster and Immune Function
摘要
Abstract
Objective:To analyze the clinical curative effect observation of Modified Longdan Xiegan decoction in the treatment of herpes zoster and its effects on the immune function.Methods:Sixty cases of patients with herpes zoster in our hospital were ran-domly divided into the control group and the observation group according to Random Number Table,30 cases in each group.The control group had oral Gabapentin capsule,the observation group had Longdan Xiegan decoction on the basis of treatment of the control group.Changes of simplified McGill pain scores,Oswestry disability index,Hamilton anxiety scale (HAMA)scores, Hamilton depression scale (HAMD)scale score were observed at 1 st week and 4th week after treatment.Th1 7 cell concentration changes before and 4 weeks after the treatment were also meatured.Results:1 )The McGill pain scores were with no statistical differences between the two groups before the treatment (P >0.05),after the treatment.McGill pain scores decreased in the two groups of patients,but the downward trend of the observation group was more obvious;2)the comparison of the Oswestry disability index were with no statistical differences between the two groups before treatment (P >0.05),after treatment,Oswestry disability index declined in the two groups of patients,the downward trend of observation group was more obvious.3)HAMA and HAMD negative emotions integral comparison of the two groups were with no statistically significant differences before treatment (P >0. 05),HAMA and HAMD negative emotions integral of the two groups were statistical differences before treatment compared to after treatment (P <0.05),the observation group decreased more significantly of HAMA and HAMD negative emotions integral (P <0. 05);(4)the human peripheral blood mononuclear cells assay of Th1 7 were detected in patients of different treatment group by u-sing flow cytometry,the results showed that:Th1 7 expression of the two groups had no obvious differences before treatment (P >0.05);Th1 7 cells expression of observation group was obviously lower than the control group1 month after the treatment.Conclu-sion:Modified Longdan Xiegan decoction can treat herpes zoster effectively,and its mechanism may be related to the improvement of Th1 7 cells in patients.关键词
带状疱疹/龙胆泻肝汤/Th17细胞Key words
Herpes Zoster/Longdan Xiegan Decoction/Th1 7 cells分类
医药卫生引用本文复制引用
白桦,刘法..龙胆泻肝汤加减对带状疱疹的临床疗效观察及对免疫功能的影响[J].世界中医药,2015,(7):1022-1025,4.基金项目
内蒙古卫生厅医疗卫生科研计划项目 （）
