色谱Issue(5)：553-557,5.DOI:10.3724/SP.J.1123.2014.01013
顶空气相色谱法同时测定人工牛黄中7种残留溶剂
Simultaneous determination of seven residual solvents in bovis calculus artifactus by headspace gas chromatography
摘要
Abstract
A headspace gas chromatography( HS-GC)method was developed for the simulta-neous determination of seven residual solvents( petroleum ether( 60-90 ℃),acetone,ethyl acetate,methanol,methylene chloride,ethanol and butyl acetate)in bovis calculus artifactus. The DB-WAX capillary column and flame ionization detector( FID)were used for the separa-tion and detection of the residual solvents,and the internal standard method was used for the quantification. The chromatographic conditions,such as equilibrium temperature and equilibri-um time,were optimized. Under the optimized conditions,all of the seven residual solvents showed good linear relationships with good correlation coefficients( not less than 0. 999 3)in the prescribed concentration range. At three spiked levels,the recoveries for the seven residual solvents were 94. 7%-105. 2% with the relative standard deviations( RSDs)less than 3. 5%. The limits of detection( LODs)of the method were 0. 43-5. 23 mg/L,and the limits of quantifica-tion( LOQs)were 1. 25-16. 67 mg/L. The method is simple,rapid,sensitive and accurate,and is suitable for the simultaneous determination of the seven residual solvents in bovis calculus artifactus.关键词
内标法/顶空气相色谱法/残留溶剂/人工牛黄Key words
internal standard method/headspace gas chromatography( HS-GC)/residual sol-vent/bovis calculus artifactus分类
化学化工引用本文复制引用
池舒耀,伍迪科,孙晋红,叶汝汉,王晓燕..顶空气相色谱法同时测定人工牛黄中7种残留溶剂[J].色谱,2014,(5):553-557,5.基金项目
广东省科技计划项目（2012B040307002）． （）
