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涂层技术在毛细管电泳手性分离中的应用

王丙香 柴微波 唐安娜 丁国生

色谱Issue(4):334-341,8.
色谱Issue(4):334-341,8.DOI:10.3724/SP.J.1123.2014.12041

涂层技术在毛细管电泳手性分离中的应用

Application of coating technology in capillary electrophoresis for chiral separation

王丙香 1柴微波 1唐安娜 2丁国生1

作者信息

  • 1. 天津大学药物科学与技术学院,天津300072
  • 2. 南开大学化学学院分析科学研究中心,天津300071
  • 折叠

摘要

Abstract

Chirality is one of the intrinsic attributes of the nature. Chiral separation and analysis are of great importance in many research fields, such as life science, environmental science, biological engineering and pharmaceutical engineering. Currently, chiral capillary electrophore⁃sis technique used for the enantioselective resolution of different kinds of racemates has become one of the most distinctive research and application fields. However, the adsorption of the analytes ( or chiral selectors) on the inner wall of the capillary is a common problem in cap⁃illary electrophoresis chiral separation. Coating technology, namely modification of the inner wall of the capillary, is the simplest and most effective way to suppress disadvantageous adsorption, and to improve the separation efficiency and analysis repeatability. In this review, the recent applications of different coating procedures in chiral analysis are presented, and the future developments in this field are also prospected.

关键词

毛细管电泳/涂层/手性分离/综述

Key words

capillary electrophoresis ( CE)/coating/chiral separation/review

分类

化学化工

引用本文复制引用

王丙香,柴微波,唐安娜,丁国生..涂层技术在毛细管电泳手性分离中的应用[J].色谱,2015,(4):334-341,8.

基金项目

国家自然科学基金项目(21005054,21275081). ()

色谱

OA北大核心CSCDCSTPCDMEDLINE

1000-8713

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