生物安全学报Issue(2)：60-71,12.DOI:10.3969/j.issn.2095-1787.2015.02.007
害虫遗传不育技术中致死基因的研究与应用
Used of lethal genes in sterile insect technique for pest control：a review
摘要
Abstract
The sterile insect technique ( SIT) is a species-specific, environment-friendly, and highly effective tool for insect pest control. Currently, release of insects carrying a dominant lethal gene ( RIDL) is one of the most studied techniques that were devel-oped to enhance traditional SIT. A standard RIDL system includes a tet-off system, gene specific promoters, components involved in sex determination and the effective lethal genes. Specifically, selecting the proper lethal genes is a very important step that deter-mines both efficiency and stability of RIDL strain. The lethal genes can be repressible, or specifically expressed in females, or di-rectly cut the X chromosome, all of which way lead to repressible/embryo-specific/female-specific lethality of offspring. Here the studies and applications of cell death genes such as RHG family ( reapr, hid, grim, michelob x) , tetracycline transcriptional activa-tor ( tTA) , Nipp1Dm and homing endonuclease genes ( HEG) are reviewed. The function mechanism and application feature of cer-tain lethal genes are discussed. More research on the structural character and regulation pathway of important lethal genes are needed to further understand cell apoptosis, as well as the development of new tools for genetic pest management.关键词
昆虫不育技术/致死基因/细胞凋亡基因/转录激活因子/归巢内切酶基因Key words
sterile insect technique/lethal genes/cell death genes/tetracycline transcriptional activator/homing endonuclease genes引用本文复制引用
王玉生,蔡玉音,武强,严盈,张桂芬,刘桂清,万方浩..害虫遗传不育技术中致死基因的研究与应用[J].生物安全学报,2015,(2):60-71,12.基金项目
环保公益性行业科研专项(201409061)；中德合作科研项目[PPP 项目,留金欧(2012)6014和留金欧(2014)6013)]；农业部2014年农作物病虫鼠害疫情监测与防治(外来入侵生物防治)项目；科技导报社博士生创新研究资助计划( kjdb201001-3) （201409061）
