生物加工过程Issue(2)：53-56,4.DOI:10.3969/j.issn.1672-3678.2015.02.010
鱼鳞胶原蛋白提取及对成纤维细胞功能的影响
Effect of fish scale collagen on fibroblast function
摘要
Abstract
Water⁃soluble collagens were isolated from fish scale,and the effect of fish scale collagen on fibroblast proliferation,PDGF and TGFβ mRNA expression,and the concentration of cGMP were studied. The results showed that the proliferation of fibroblasts was upregulated in a dose⁃dependent manner,and the relative growth rate was increased 42�75% treated with scale collagen (40 mg/L) PDGF,TGFβmRNA expression and protein production were significantly promoted,and treating with scale collagen (40 mg/L) ,the relative mRNA expression of PDGF and TGFβ were increased 1�514 ± 0�047 and 1�595 ± 0�032. Water⁃soluble fish scale collagen were biocompatible,could enhance fibroblast cell activity,and would be favorable as wound healing material.关键词
鱼鳞胶原蛋白/成纤维细胞/伤口愈合Key words
fish scale collagen/fibroblast/wound healing分类
医药卫生引用本文复制引用
朱伟,张晓莉,刘洋,王小花,李玉婷..鱼鳞胶原蛋白提取及对成纤维细胞功能的影响[J].生物加工过程,2015,(2):53-56,4.基金项目
黑龙江省教育厅科学技术研究项目 （）
