生物技术通报Issue(11)：24-31,8.
哺乳动物中RNA干扰沉默基因表达的研究进展
Research Progress of Gene Silencing by RNA Interfering Technology in Mammal
摘要
Abstract
Variation of metabolic pathways result from RNA interference and related RNA silencing pathways have revolutionized our understanding of gene regulation. Gene silencing has been used as a research tool to control the expression of specific genes in numerous experimental organisms. Importing the different cells with specific siRNA need different transfection reagent to achieve maximum transfection efficiency, and will not produce larger cell toxicity. In recent years, new nano-material such as carbon nanotubes exert interference effect expanding us the traditional liposomes and virus’ understanding. The rapid progress in the field of RNA interference was summarized, and then compare different RNA interference experiments used several different carriers. Further, the perspectives of future research on RNA interference mediated from traditional liposomes to virus and polymer nano-material in disease treatment and clinic diagnose were proposed.关键词
RNA干扰/小干扰RNA/基因沉默/转染/碳纳米管Key words
RNA interference/Small interfering RNA/Gene silencing/Transfection/Carbon nanotubes引用本文复制引用
曹腾威,谷凌云,黄和,高振,郦明芳..哺乳动物中RNA干扰沉默基因表达的研究进展[J].生物技术通报,2014,(11):24-31,8.基金项目
国家自然科学基金项目 （）
