生物技术通报Issue(4)：105-119,15.DOI:10.13560/j.cnki.biotech.bull.1985.2015.03.005
表观遗传学及现代表观遗传生物医药技术的发展
The Developments of Epigenetics and Epigenetics-based Modern Biomedicine and Pharmaceutics
摘要
Abstract
Epigenetics and epigenetic mechanism-based biomedical technologies have emerged as important research fields in post-genomic area. In-depth investigation on epigenetic alterations of DNA methylation, histone modifications, non-coding RNAs, etc. in tumorigenesis, cardiovascular disease, diabetes, and neurodegenerative diseases associated with the elderly population is not only beneficial to the understanding of the molecular pathogenesis of the diseases, but also useful in exploring effective treatments based upon epigenetic mechanisms. This review first briefly introduces epigenetic modification mechanisms, then summarizes current research progress on abnormal epigenetic modifications in the disease conditions, and also discusses the relevant biomedical technology.关键词
表观遗传学/DNA甲基化/组蛋白翻译后修饰/非编码RNA/人类疾病Key words
epigenetics/DNA methylation/histone post-translational modification/non-coding RNA/human diseases引用本文复制引用
姜楠,潘学峰..表观遗传学及现代表观遗传生物医药技术的发展[J].生物技术通报,2015,(4):105-119,15.基金项目
北京市自然科学基金项目（5132014），北京理工大学自然科学基础基金项目 （）
