生物信息学Issue(1)：40-46,7.DOI:10.3969/j.issn.1672-5565.2015.01.08
细胞信号网络功能鲁棒的简并性拓扑特征
Degenerate topology analysis of robustness in cellular signaling network
摘要
Abstract
Cellular signaling network shows good robustness during interference, but the intrinsic mechanism about it is still not clear. This study aims to analyze the topological structure properties of the cellular signaling network. Boolean network was used to simulate the dynamic cellular signaling network, and the disturbance of network nodes was used to simulate the interference of external environment. The function of different topological networks was explored by using evolutionary strategy to analyze their robustness under various interference environments. By adopting the quantitative definitions proposed by Edelman et al, we measured the topological characteristics of degeneracy, redundancy and complexity in the evolved Boolean networks, and compared their mechanism and contributions to the robustness. As is shown in the results, in the progress of evolution of the network, the degeneracy is positivly correlatlive with the robustness significantly, and the correlation coefficient between the degeneracy and the robustness is better than that between the redundancy and the robustness. And network nodes and complexity increase with the robustness. They also have a better correlation with degeneracy than that with redundancy,which demonstrates that the increased nodes improve the robustness and complexity in a degenerate way. Therefore, the topology characteristic of cellular signaling network is the degeneracy rather than the redundancy. The degeneracy provides an efficient method for solving the complex problems of biology system and offers references for the reliability design of manual system.关键词
细胞信号网络/布尔网络模型/简并性/冗余性/鲁棒性Key words
Cellular signaling network/Boolean network/Degeneracy/Redundancy/Robustness分类
数理科学引用本文复制引用
满梦华,张娅,蔡娜,马贵蕾,原亮,褚杰..细胞信号网络功能鲁棒的简并性拓扑特征[J].生物信息学,2015,(1):40-46,7.基金项目
国家自然科学基金（ No．51407194，No．51207167）。 （）
