护理研究Issue(25)：3093-3095,3.DOI:10.3969/j.issn.10096493.2014.25.009
不同换药方式对糖尿病模型小鼠和正常小鼠创面愈合影响的实验研究
Experimental study on influence of different dressing changes on wound healing in diabetic model mice and normal mice
摘要
Abstract
Obj ective:To compare the influence of 3 clinical common nursing dressing methods including physiological saline,4% boric acid solution,and 0.5% iodophor +3% hydrogen peroxide on wound healing in diabetic mice and normal mice,so as to explore the most suitable nursing dressing changes for diabetic refractory wound.Methods:A total of 30 male C57BL/6J mouse at age of 8 weeks were taken and divided in-to diabetic group and control group,1 5 cases in each.The streptozotocin (STZ induced)was placed on the back of diabetic mouse to make 3 equal sized full thickness skin wounds in them,and then the normal saline (A treatment),4% boric acid solution (B treatment)and 0.5% io-dophor +3% hydrogen peroxide solution (C treatment)were used re-spectively for dressing changes of three wounds once a day.The wound scab and infection were recorded and the wound healing rate was calcu-lated.Results:At the same time point,in A treatment wound healing rate of diabetic mice in diabetic group was significantly lower than that in control group;there was not statistically significant difference in wound healing rate of control group mouse among 3 different dressing treatment (P>0.05);the wound healing rate in diabetic mouse using B treatment was significantly higher than that of A and C treatments (P<0.05).Conclusion:3 kinds of dressing changes applied for wounds in normal mice have no significant influence on wound healing rate;boric acid solution used for wounds dressing changes in diabetic mice is more conducive to wound healing compared with other dressing changes.关键词
糖尿病/难愈性创面/换药/伤口愈合Key words
diabetes/refractory wound/dressing change/wound healing分类
医药卫生引用本文复制引用
邓洁,罗羽..不同换药方式对糖尿病模型小鼠和正常小鼠创面愈合影响的实验研究[J].护理研究,2014,(25):3093-3095,3.基金项目
国家自然科学基金项目,编号:31271239 （）
厦门大学细胞应激生物学国家重点实验室开放课题基金、细胞生物学与肿瘤细胞工程教育部重点实验室访问学者基金资助。 （）
