陕西师范大学学报（自然科学版）Issue(4)：57-64,8.
转化生长因子-β1与硒蛋白P在慢性应激性抑郁发生中的作用及关系
Involvement of transforming growth factor beta-1 and selenoprotein P in depression induced by chronic stress
摘要
Abstract
In order to investigate the role and relationship between transforming growth factor-beta1 (TGF-β1 )and selenoprotein P in depression induced by chronic unpredictable mild stress (CUMS),the effects of intrahippocampal microinjections of TGF-β1 and its receptor kinase inhibitor (LY-364947 ) on CUMS-induced depression and anxiety-like behaviors were investigated.The levels of depression like behaviors and related properties were measured using open-field test,tail suspension test,sucrose consumption and the body weight.The content level of TGF-β1 and the selenoprotein P were detected by Elisa and Western blot respectively.The results show that compared with control group,CUMS rats showed significant depression-like behaviors,lower levels of selenoprotein P and higher levels of TGF-β1 in the hippocampus.Microinj ection of recombined TGF-β1 didn′t result in increase of depressive-like behaviors;however,intrahippocampal inj ection of recombined TGF-β1 can effectively reduced the depressive-like behaviors induced by CUMS.TGF-β1 inhibited the expression of selenoprotein P.Interestingly, microinj ection of LY-3 6 4 9 4 7 ,the inhibitor of TGF-beta type 1 receptor kinase into hippocampus also showed anti-depression effect and the expression of selenoprotein P was higher compared with CUMS/SAL group.These data suggest that selenoprotein P and TGF-β1 in the hippocampus are involved in chronic stress induced depression.Selenoprotein P may play a role in the protection of hippocampus.It may be involved in the occurrence of depression in which TGF-β1 inhibits the expression of selenoprotein P via TGF-beta type 1 receptor .The antidepressant effects of TGF-beta 1 may be via other ways without the TGF-beta type 1 receptor.关键词
应激/抑郁/转化生长因子-β1/硒蛋白PKey words
stress/depression/transforming growth factor beta 1/selenoprotein P分类
生物科学引用本文复制引用
李菲,陈慧彬,吴帅,安书成..转化生长因子-β1与硒蛋白P在慢性应激性抑郁发生中的作用及关系[J].陕西师范大学学报（自然科学版）,2014,(4):57-64,8.基金项目
国家自然科学基金资助项目（81271488）；中央高校基本科研业务费专项资金项目（GK200901011）． （）
