陕西师范大学学报（自然科学版）Issue(2)：74-78,5.DOI:10.15983/j.cnki.jsnu.2015.02.226
化学修饰杏鲍菇多糖对 K562细胞的抑制作用
Studies on inhibition effect on K562 cells of chemical modified polysaccharide of Pleurotus eryngii
摘要
Abstract
The polysaccharides were extracted from Pleurotus eryngii by alkali solution,then were modified by sulfation,phosphorylation,and acetylation.The corresponding antitumor activities have been studied.The structure of modified and unmodified Pleurotus eryngii alkali polysaccha-ride (PEAP)was tested by the infrared spectroscopy.Then the antitumor ability were tested by MTT assay in vitro.The results show that the characteristic absorption peaks of sulfuric group, phosphate group and acetyl group were observed respectively.The ability of the anti-tumor Hu-man Leukemia Cell K562 activity of the chemical modified PEAP were all improved and the acety-lated modified PEAP (Ac-PEAP)has the best inhibitory ability.关键词
杏鲍菇/多糖/化学修饰/抗肿瘤活性Key words
Pleurotus eryngii/polysaccharide/chemical modification/antitumor activity分类
医药卫生引用本文复制引用
陈琳,郝长春,梁涛,南征,孙润广..化学修饰杏鲍菇多糖对 K562细胞的抑制作用[J].陕西师范大学学报（自然科学版）,2015,(2):74-78,5.基金项目
国家自然科学基金资助项目（21402114）；陕西省自然科学基础研究计划（2012JQ1002）；中央高校基本科研业务费专项资金项目 （）
