山西医科大学学报Issue(1)：1123-1126,4.DOI:10.13753/j.issn.1007-6611.2014.12.002
TNF-β+252基因多态性及幽门螺杆菌感染与胃癌易感性的关系
Association of tumor necrosis factor-β(+252)gene polymorphism and H. pylori infection with susceptibility of gastric cancer
摘要
Abstract
Objective To investigate the distribution of tumor necrosis factor-β( TNF-β) +252 mononucleotide polymorphisms in pa-tients with gastric cancer( GC) and healthy controls,and to evaluate the effect of TNF-β polymorphisms and H. pylori infection on the susceptibility of gastric cancer. Methods A total of 118 GC patients( GC group) and 107 healthy controls( control group) were en-rolled in this study. The genetic polymorphisms of TNF-β+252 were determined by PCR-RFLP,and H. pylori infection was deter-mined by ELISA assay. The relationship among TNF-β+252 polymorphisms,H. pylori infection and the susceptibility to GC was as-sessed. Results There was no significant difference in the frequencies of three genotypes and two alleles of TNF-β+252 gene be-tween GC group and control group ( P>0. 05 ) . The rate of H. pylori infection was significantly higher in GC group than in control group(P<0. 01). Stratification analysis showed that the frequency of allele A(genotype G/A and A/A)with H. pylori infection was sig-nificantly higher in GC group than in control group(P=0. 047). Conclusion The interaction of TNF-β+252 A>G polymorphism and H. pylori infection may increase the susceptibility to GC.关键词
胃癌/TNF-β/基因多态性/单核苷酸/幽门螺杆菌Key words
gastric cancer/TNF-β/gene polymorphism/mononucleotide/H. pylori分类
医药卫生引用本文复制引用
陶梅,张玲霞,宋瑛,庄坤,张宁霞,张沥..TNF-β+252基因多态性及幽门螺杆菌感染与胃癌易感性的关系[J].山西医科大学学报,2015,(1):1123-1126,4.基金项目
陕西省科技攻关基金资助项目(2008k09-03) （2008k09-03）
