山西医科大学学报Issue(1)：1177-1179,3.DOI:10.13753/j.issn.1007-6611.2014.12.016
COPD急性期患者血清白介素13及胱抑素C水平与肺功能的关系
Relevance of serum interleukin 13 and cystatin C level to lung function in COPD patients at acute stage
郭素娟 1牛莉娜 2牛丽鑫 3肖胜霞4
作者信息
- 1. 河北省石家庄市新乐市医院呼吸科，新乐 050700
- 2. 河北省石家庄市新乐市医院儿科
- 3. 河北省石家庄市新乐市医院眼科
- 4. 河北省石家庄市新乐市医院药房
- 折叠
摘要
Abstract
Objective To investigate the changes of serum interleukin 13 and cystatin C( CysC) in chronic obstructive pulmonary dis-ease( COPD) patients at acute stage,and explore their relations hip with lung function. Methods Fifty-six COPD patients at acute stage were selected as experimental group,and 27 healthy volunteers were chosen as control group. The serum levels of IL-13 and CysC were detected by ELISA in two groups,and the lung function in experimental group was determined within 24 h. Results Compared with control group,serum IL-13,Cys-C levels were increased in experimental group(P<0. 05). Forced vital capacity(FVC) and peak expiratory flow(PEF) were significantly lower in experimental group than in control group(P<0. 05). Serum IL-13,CysC levels were negatively correlated with FVC(r= -0. 849,r= -0. 787,P<0. 05),and PEF(r= -0. 788,r= -0. 698,P<0. 05). Conclusion Serum IL-13 and CysC levels in COPD patients at acute stage are significantly higher than those in healthy subjects,and are negatively correlated with lung function.关键词
慢性阻塞性肺疾病/白介素13/胱抑素C/用力肺活量/最大呼气峰流速Key words
chronic obstructive pulmonary disease/interleukin 13/cystatin C/forced vital capacity/peak expiratory flow分类
医药卫生引用本文复制引用
郭素娟,牛莉娜,牛丽鑫,肖胜霞..COPD急性期患者血清白介素13及胱抑素C水平与肺功能的关系[J].山西医科大学学报,2015,(1):1177-1179,3.
