山西医科大学学报Issue(1)：1180-1182,3.DOI:10.13753/j.issn.1007-6611.2014.12.017
标准三联加益生菌疗法和铋剂四联方案治疗幽门螺杆菌感染的对照研究
Control study on standard triple therapy combined with probiotics and bismuth quadruple therapy in treatment of anti-Helico-bacter pylori eradication
谢睿 1杨晓钟 1高成城 1吴尚农 1马天恒1
作者信息
- 1. 南京医科大学附属淮安第一医院消化科，淮安 223300
- 折叠
摘要
Abstract
Objective To explore the effects of standard triple therapy combined with probiotics versus bismuth quadruple therapy on the eradication rates and adverse effect in anti-Helicobacter pylori( Hp) therapy. Methods A total of 150 Hp-infected patients with chronic active gastritis diagnosed by 13 C-urea breath test( 13 C-UBT) were enrolled and randomly assigned into three groups. Patients in group A were given standard triple therapy( clarithromycin,amoxicillin and rabeprazole) combined with bifid-triple viable capsules( bifi-co). Patients in group B were given bismuth quadruple therapy(clarithromycin,amoxicillin,rabeprazole and bismuth potassium citrate capsules) . Patients in group C were given standard triple therapy. Each course of treatment was 10 d. Adverse effects were observed dur-ing the treatment. Four weeks after the treatment,13 C-UBT was re-performed to assess Hp eradication rate. Results A total of 139 pa-tients completed the study. Hp eradication rates were 78. 0%, 76. 0%, 56. 0% by intention-to-treat(ITT)analysis and 81. 3%, 86. 4%, 59. 6% by per-protocol(PP)analysis in groups A,B and C,respectively. The eradication rates in group A and B were significantly higher than that in group C by both ITT and PP analysis(P<0. 05),but there was no significant difference between group A and group B. The incidence of side effects was significantly lower in group A than those in group B and group C(33. 3% vs 61. 4% and 55. 3%,P<0. 05), but no significant difference was found between group B and group C(P>0. 05). The drug tolerance in group A was significantly higher than those in group B and group C(P<0. 05). Conclusion Both standard triple therapy combined with probiotic and bismuth quad-ruple therapy can greatly improve the Hp eradication rate,while probiotics can greatly reduce the incidence of adverse effect.关键词
益生菌/幽门螺杆菌/慢性胃炎Key words
probiotics/Helicobacter pylori/chronic gastritis分类
医药卫生引用本文复制引用
谢睿,杨晓钟,高成城,吴尚农,马天恒..标准三联加益生菌疗法和铋剂四联方案治疗幽门螺杆菌感染的对照研究[J].山西医科大学学报,2015,(1):1180-1182,3.
