山西医科大学学报Issue(1)：1193-1196,4.DOI:10.13753/j.issn.1007-6611.2014.12.021
DC-CIK细胞免疫治疗联合化疗对卵巢癌免疫功能的影响
Effect of dendritic cell-cytokine-induced killer cells combined with chemotherapy on immunological function in patients with malignant ovarian tumor
王文翔 1范文强 2董学彩 1高玉霞 1海静 1程萍 3陈彩霞1
作者信息
- 1. 新乡市中心医院妇科妇瘤科，新乡453000
- 2. 新乡市中心医院风湿免疫科
- 3. 新乡市中心医院生物治疗中心
- 折叠
摘要
Abstract
Objective To evaluate the curative effecacy of dentritic cell(DC)-cytokine induced killer cells(CIKs) combined with chem-otherapy in treatment of ovarian carcinoma by investigating the changes of T lymphocyte subsets in peripheral blood. Methods Clini-cal data and the changes of lymphocyte subsets in 62 patients with ovarian carcinoma,who were admitted to Central Hospital of Xinxiang from September 2011 to August 2013,were retrospectively reviewed. Thirty patients were treated by DC-CIK combined with chemothera-py( taxel+cisplatin) in combination group,while 32 patients were treated with chemotherapy alone in control group. Three weeks were designed as one course of treatment, and the curative effects were evaluated at 7 d after treatment. The immune functions ( CD3 +, CD3 +CD4 +,CD4 + /CD8 +,CD4 +CD25 +T,NK cells) were evaluated in two groups one week after treatment. Results After three courses of treatment,the levels of CD3 +,CD3 +CD4 +,CD4 + /CD8 +,NK cells in peripheral blood were statistically significantly higher in combination group than in control group(P<0. 05). The disease control rate(DCR)in combination group was higher than that in con-trol group(85. 7% vs 56. 5%,P<0. 05). The incidence of side effects(including bone marrow suppression,impaired liver function)was lower in combination group than in control group(P<0. 05). The physical condition and appetite of the patients in combination group were better than those in control group. Conclusion Treatment with DC-CIK cells immune therapy combined with chemotherapy can improve the immunological function in patinents with ovarian carcinoma,and it is safe and effective.关键词
卵巢癌/DC-CIK细胞免疫治疗/流式细胞术/T淋巴细胞亚群Key words
ovarian carcinoma/DC-CIK cell immune therapy/flow cytometry/T lymphocyte subsets分类
医药卫生引用本文复制引用
王文翔,范文强,董学彩,高玉霞,海静,程萍,陈彩霞..DC-CIK细胞免疫治疗联合化疗对卵巢癌免疫功能的影响[J].山西医科大学学报,2015,(1):1193-1196,4.
