现代检验医学杂志Issue(5)：77-80,4.DOI:10.3969/j.issn.1671-7414.2014.05.018
多发性骨髓瘤分子细胞遗传学异常相关性研究
Study on the Related Molecular and Cytogenetic Abnormalities in Multiple Myeloma
史沛芹 1王文婷 1朱学涛 1汪海清 1杨艳1
作者信息
- 1. 连云港市第一人民医院检验科，连云港 222000
- 折叠
摘要
Abstract
Objective To explore the molecular and cytogenetic abnormalities in multiple myeloma (MM).Methods The la-boratory data of bone marrow smears were retrospectively analyzed in 61 patients of MM.24 hours short-term culture of bone marrow and R banding technology were performed in 31 patients.Among these patients,10 cases were selected for de-tecting the IgH gene expression by the interval FISH method.Results The proportions of myeloma cells were 0.19~0.94 in bone marrow smears of 61 patients.In 31 patients,25 patients had enough metaphases for analysis,in which 19 cases (71.3%)had abnormal clones,8q24,11q13,13q14 and 17p13 were important structural abnormalities,where 14q32 rear-rangement was the most characteristic abnormal structure,6 patients were detected IgH gene rearrangement.Conclusion Bone marrow smear combined with other laboratory examinations could make the diagnosis of MM,chromosomal abnormali-ties may help to explore the pathogenesis of MM,and provide a theoretical basis for the early diagnosis,treatment and prog-nosis of this disease.关键词
多发性骨髓瘤/染色体异常/IgH基因Key words
multiple myeloma/chromosomal abnormalities/IgH gene分类
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史沛芹,王文婷,朱学涛,汪海清,杨艳..多发性骨髓瘤分子细胞遗传学异常相关性研究[J].现代检验医学杂志,2014,(5):77-80,4.
