现代检验医学杂志Issue(5)：89-92,4.DOI:10.3969/j.issn.1671-7414.2014.05.022
白细胞介素-10基因多态性与子宫内膜异位症易感性关系的Meta分析
Meta-Analysis on Interleuki-1 0 Polymorphisms and Endometriosis Susceptibility
孙京花 1陈旭 2苏显都 3范长玲 3王海 1王成彬 1李健1
作者信息
- 1. 解放军总医院检验科，北京 100853
- 2. 广西医科大学第一附属医院检验科，南宁 530000
- 3. 海南农垦那大医院检验科，海南儋州 571700
- 折叠
摘要
Abstract
Objective To evaluate the association between interleukin-10(IL-10 )polymorphisms and endometriosis suscepti-bility by meta-analysis.Methods Computer retrieval Pubmed,Embase,Chinese HowNet,Chinese biomedical and Wanfang database.Published data relating to case-control studies reporting the link between IL-10 polymorph-isms and endometriosis were retrieved.Meta-analysis was conducted to determine whether the IL-10 gene polymorphisms were associated with endo-metriosis.Results Six studies were finally accepted for analysis.There were five studies focused on-819T/C polymorphism and six studies focused on-592A/C polymorphism.The odds ratio of each genetype for endometriosis:TT/CC,TC/CC,AA/CC and AC/CC were 0.90(0.81~0.99),P<0.05;0.92(0.82~1.02),P>0.05;0.92(0.79~1.07),P>0.05;0.98(0.90~1.06),P>0.05.No significant publication bias was found regarding TT/CC,TC/CC,AA/CC and AC/CC genotypes(P=0.81,0.81,0.71,0.26).Conclusion IL-10 gene-819TT genotypes may be a protetive factor of endometriosis.There was no related to show that other genotypes in position-819 and-592 were associated with endometriosis.关键词
子宫内膜异位症/白细胞介素-1 0/多态性/Meta分析Key words
endometriosis/interleukin-10/polymorphism/meta-analysis分类
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孙京花,陈旭,苏显都,范长玲,王海,王成彬,李健..白细胞介素-10基因多态性与子宫内膜异位症易感性关系的Meta分析[J].现代检验医学杂志,2014,(5):89-92,4.
