现代检验医学杂志Issue(5)：123-126,4.DOI:10.3969/j.issn.1671-7414.2014.05.033
血清VEGF，SCC-Ag和CYFRA21-1对中晚期肺鳞癌化疗疗效评估的价值
Value of Serum VEGF,SCC-Ag and CYFRA2 1-1 for Predicting Eesponse to Chemotherapy in Advanced Lung Squamous Cell Carcinoma
顾金花 1陈玲 1周丽娜 2王李强 2顾涛1
作者信息
- 1. 江苏大学附属昆山医院 检验中心，江苏昆山 215300
- 2. 江苏大学附属昆山医院 肿瘤科，江苏昆山 215300
- 折叠
摘要
Abstract
Objective To investigate the combined detection of serum vascular endothelial growth factor (VEGF),squamous cell carcinoma antigen (SCC-Ag)and cytokeratin 19 fragment (CYFRA21-1)value in assessing the efficacy of chemotherapy in patients with advanced squamous cell carcinoma of the lung.Methods 60 cases of lung squamous cell carcinoma patients in January 2011 between June 2013 to be admitted to hospital were treated with gemcitabine plus cisplatin or carboplatin chemotherapy.Detected the levels of serum VEGF,SCC-Ag and CYFRA21-1 expression in 60 cases before and after 1 cycle of chemotherapy in patients using ELISA and immunoradiometric assay,and evaluated the efficacy evaluation with reference to RECIST criteria after 2 cycle of chemotherapy.Results Effective group serum VEGF and CYFRA21-1 levels were 413± 114 pg/ml and 14.7±9.6 ng/ml;serum VEGF and CYFRA21-1 levels after one cycle of chemotherapy were 272±131 pg/ml and 10.8±7.1 ng/ml,which decreased after chemotherapy (P<0.01).Progress group serum VEGF and CYFRA21-1 levels were 472±207 pg/ml and 18.9±17.6 ng/ml;serum VEGF and CYFRA21-1 levels after one cycle of chemotherapy were 537±219 pg/ml and 21.5±20.2 ng/ml,which increased after chemotherapy (P<0.01).Stable group serum VEGF CYFRA21-1 levels and were 419±246 pg/ml and 17.0±12.9 ng/ml;serum VEGF and CYFRA21-1 levels after one cycle of chemotherapy were 421±252 pg/ml and 16.8±11.7 ng/ml,which had no changes before and after treatment (P>0.05). Serum SCC-Ag levels before and after each treatment group difference was not statistically significant (P>0.05).Multiple regression analysis showed that serum VEGF,CYFRA2 1-1 levels and the efficacy of lung squamous were related changed (t=5.86,P<0.001;t=2.26,P=0.027),and there was no significant correlation between SCC-Ag levels changes and the effect of chemotherapy (t=1.52,P=0.133).Conclusion Serum VEGF and CYFRA21-1 expression level changes associat-ed with squamous cell carcinoma of the lung chemotherapy effect,which can advance understanding of the effect of chemo-therapy,combined with advanced squamous cell carcinoma detection of serum VEGF and chemotherapy assessment CY-FRA2 1-1 has a certain reference value.关键词
肺癌/血清/肿瘤指标/化疗Key words
lung cancer/serum/tumor marker/chemotherapy分类
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顾金花,陈玲,周丽娜,王李强,顾涛..血清VEGF，SCC-Ag和CYFRA21-1对中晚期肺鳞癌化疗疗效评估的价值[J].现代检验医学杂志,2014,(5):123-126,4.
